{"id":"W3187302100","doi":"10.1002/onco.13927","title":"Next-Generation Sequencing in the Diagnosis of Metastatic Lesions: Reclassification of a Glioblastoma as an Endometrial Cancer Metastasis to the Brain","year":2021,"lang":"en","type":"article","venue":"The Oncologist","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"PTEN; Medicine; Microsatellite instability; Endometrial cancer; Metastasis; Pathology; Brain metastasis; KRAS; Immunohistochemistry; Cancer; Lesion; Oncology; Internal medicine; Colorectal cancer; Biology; Microsatellite; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001178577,0.0000978341,0.0001742458,0.00004796403,0.00009959366,0.0000366658,0.0003486847,0.00005027857,0.00003010409],"category_scores_gemma":[0.002531533,0.00005538466,0.00008138678,0.0004767137,0.0001154635,0.00000581,0.00009009318,0.00008054134,0.000001784503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009532094,"about_ca_system_score_gemma":0.0005404224,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001877836,"about_ca_topic_score_gemma":0.01965981,"domain_scores_codex":[0.998621,0.0005421634,0.0003232349,0.0002164609,0.0001637522,0.0001333622],"domain_scores_gemma":[0.998542,0.0005749234,0.0001943858,0.0005120169,0.0001479763,0.00002865845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003221466,0.0002194176,0.0006983888,0.00001982472,0.000115608,0.00000688219,0.001371061,0.009489606,0.9320752,0.001908959,0.006714801,0.04705812],"study_design_scores_gemma":[0.00101122,0.001497745,0.001999991,0.00003125204,0.0002025922,0.00001961304,0.005148411,0.0007807583,0.9495119,0.000457867,0.03916746,0.0001711248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883334,0.002249112,0.0004816013,0.00805291,0.0001859383,0.000446691,0.000116037,0.000002226873,0.0001321024],"genre_scores_gemma":[0.9954356,0.001735675,0.0005529836,0.001583535,0.0002420143,0.0003458819,0.00005492805,0.000009589764,0.00003977306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.046887,"threshold_uncertainty_score":0.9982288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.137793161153583,"score_gpt":0.3627381149925187,"score_spread":0.2249449538389357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}