{"id":"W3187313271","doi":"10.1093/ecco-jcc/jjab140","title":"Impact of Drug Approval Pathways for Paediatric Inflammatory Bowel Disease","year":2021,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; University of Toronto; Children's Hospital of Western Ontario; University of Calgary; Robarts Clinical Trials; Western University","funders":"","keywords":"Medicine; Dosing; Inflammatory bowel disease; Intensive care medicine; Drug development; Orphan drug; Food and drug administration; Drug; Drug approval; Off-label use; Population; Clinical trial; Disease; Pharmacology; Bioinformatics; Internal medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03612227,0.0003323748,0.0004737021,0.00434886,0.000659388,0.004988763,0.0008308399,0.0009838018,0.008395255],"category_scores_gemma":[0.1082377,0.0003155341,0.001350527,0.005533829,0.0009229401,0.003876481,0.0016053,0.002156804,0.0008657235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005520991,"about_ca_system_score_gemma":0.0102945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005124541,"about_ca_topic_score_gemma":0.006692569,"domain_scores_codex":[0.9623958,0.01764954,0.007063794,0.002798504,0.008564559,0.001527712],"domain_scores_gemma":[0.714659,0.1533816,0.1004267,0.004665237,0.02257248,0.00429491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002499061,0.0002084584,0.4517255,0.01028195,0.0005876212,0.001998655,0.001313923,0.006807668,0.001798594,0.02342148,0.0284041,0.470953],"study_design_scores_gemma":[0.000263871,0.001102864,0.4983418,0.01139527,0.0009523127,0.00698706,0.001804771,0.004006919,0.004884651,0.007665841,0.4624327,0.0001619323],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4309129,0.3409195,0.02251993,0.09006994,0.001504033,0.0012961,0.0343998,0.0006476924,0.07773012],"genre_scores_gemma":[0.9068754,0.05481682,0.01895991,0.00739261,0.0006513033,0.0003980901,0.008375547,0.0001504596,0.002379848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03612227,"threshold_uncertainty_score":0.1910352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00625268282156306,"score_gpt":0.234799332979771,"score_spread":0.2285466501582079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}