{"id":"W3187316450","doi":"10.1530/rep-21-0134","title":"Metabolism-driven post-translational modifications of H3K9 in early bovine embryos","year":2021,"lang":"en","type":"article","venue":"Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Ministère de l'Agriculture, des Pêcheries et de l'Alimentation","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Blastocyst; Histone; Embryo; Histone H3; Acetylation; Methylation; Chemistry; Metabolism; Biology; Epigenetics; Andrology; Cell biology; Embryogenesis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001857879,0.0001949166,0.0002558022,0.0003032231,0.0001795829,0.0003862762,0.0001767542,0.0002374946,0.0008314747],"category_scores_gemma":[0.0002199184,0.000234407,0.0002246131,0.0002173406,0.0001526146,0.0002013166,0.0002149478,0.0004159804,0.0002950907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004585769,"about_ca_system_score_gemma":0.0002293814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004640229,"about_ca_topic_score_gemma":0.006268688,"domain_scores_codex":[0.9998425,0.00001677271,0.00001606737,0.00005544513,0.00003709418,0.00003202907],"domain_scores_gemma":[0.9998827,0.00002446245,0.0000358725,0.00001304259,0.0000192896,0.00002454766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001800352,0.000005824634,0.001220394,0.00003313582,0.000004558855,0.00003211275,0.00002671397,0.00004219029,0.997359,0.00002670869,0.000009888053,0.001059605],"study_design_scores_gemma":[0.00001909559,0.0003479602,0.1467789,0.00002461981,0.00004456414,0.0003364903,0.0001476493,0.0007822298,0.8475359,0.0001023485,0.00385936,0.00002091635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876201,0.005299932,0.003769306,0.00005610131,0.00002872236,0.00002834845,0.00121558,0.00002740775,0.001954588],"genre_scores_gemma":[0.9911254,0.002148175,0.002388421,0.00006614739,0.000008300703,0.00004449404,0.001180152,0.00002980481,0.003009191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004640229,"threshold_uncertainty_score":0.009226441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01420287059117066,"score_gpt":0.2607129745739747,"score_spread":0.246510103982804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}