{"id":"W3187316450","doi":"10.1530/rep-21-0134","title":"Metabolism-driven post-translational modifications of H3K9 in early bovine embryos","year":2021,"lang":"en","type":"article","venue":"Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Ministère de l'Agriculture, des Pêcheries et de l'Alimentation","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Blastocyst; Histone; Embryo; Histone H3; Acetylation; Methylation; Chemistry; Metabolism; Biology; Epigenetics; Andrology; Cell biology; Embryogenesis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001707679,0.00006529327,0.00009203024,0.0000554892,0.00002915616,0.000007297981,0.0000471912,0.00007521651,0.00001855658],"category_scores_gemma":[0.0001759606,0.0000731063,0.00005362402,0.000180036,0.0000278427,0.000006231853,0.00001891961,0.00005099904,0.000003749208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005658977,"about_ca_system_score_gemma":0.00008371488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004932502,"about_ca_topic_score_gemma":0.00005179619,"domain_scores_codex":[0.9991694,0.0000640922,0.0002256105,0.0003458278,0.0001091373,0.00008594328],"domain_scores_gemma":[0.9992154,0.000004928973,0.00007226069,0.0003778373,0.0003061455,0.00002339988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003109156,0.00008640566,0.006806562,0.000009945407,0.00001567496,4.041794e-7,0.00009406274,0.001900483,0.9869176,0.000555079,0.00002101726,0.00356168],"study_design_scores_gemma":[0.0002036779,0.0000444798,0.2261886,0.000004516145,0.00001246201,0.00000250762,0.00002894323,0.0001079625,0.766192,0.0004076342,0.006734693,0.00007249905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992174,0.003690103,0.002588801,0.0005969008,0.0001935014,0.0001042573,0.00001902865,0.000005556248,0.0006278697],"genre_scores_gemma":[0.9960523,0.0003695019,0.002412954,0.00001004908,0.0002379741,0.00001115041,0.0003101812,0.000009876982,0.0005860089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2207256,"threshold_uncertainty_score":0.2981189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01420287059117066,"score_gpt":0.2607129745739747,"score_spread":0.246510103982804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}