{"id":"W3187378736","doi":"10.3389/fnagi.2021.719507","title":"Nerve Growth Factor Compromise in Down Syndrome","year":2021,"lang":"en","type":"review","venue":"Frontiers in Aging Neuroscience","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute on Aging","keywords":"Basal forebrain; Nerve growth factor; Cholinergic neuron; Neuroscience; Cholinergic; Atrophy; Forebrain; Alzheimer's disease; Psychology; Central nervous system; Internal medicine; Endocrinology; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000357381,0.0007268736,0.0009000255,0.001776298,0.0001841486,0.0005123055,0.0006010629,0.0006894282,0.002214052],"category_scores_gemma":[0.0006654217,0.0001527956,0.0003082337,0.001207597,0.0002725451,0.0005509697,0.0004410393,0.0008352112,0.0009054185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004710165,"about_ca_system_score_gemma":0.0006603373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001535646,"about_ca_topic_score_gemma":0.002671552,"domain_scores_codex":[0.9998889,0.00001546322,0.00002486203,0.00002486991,0.00003387271,0.00001198395],"domain_scores_gemma":[0.9998265,0.00008791208,0.0000305916,0.00000393948,0.00003632895,0.00001470749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000880209,0.00002599562,0.0004316749,0.01362246,0.0001121086,0.0005321468,0.00004096754,0.0001545919,0.001186394,0.001647091,0.01890436,0.9632541],"study_design_scores_gemma":[0.00003978765,0.0001677112,0.005157338,0.01388675,0.00054104,0.01242774,0.0001235468,0.0001746198,0.0013354,0.002810224,0.9632999,0.00003596691],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001948366,0.9989182,0.00006054273,0.0001465501,0.000107681,0.000002175756,0.00001634317,0.00000549231,0.0005482422],"genre_scores_gemma":[0.0009815596,0.9983583,0.00009686602,0.0001187004,0.000102257,0.000003561676,0.00003593092,8.824253e-7,0.0003018759],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002214052,"threshold_uncertainty_score":0.007406712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09323838024319707,"score_gpt":0.3701283556317743,"score_spread":0.2768899753885772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}