{"id":"W3187516960","doi":"10.1016/j.devcel.2021.07.006","title":"Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy","year":2021,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":197,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Instituto Mexicano del Petróleo; Azrieli Foundation; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Ministero dell’Istruzione, dell’Università e della Ricerca; Human Frontier Science Program; Ministero della Salute; Fondazione Cariplo; Università degli Studi di Milano; Centre National de la Recherche Scientifique; Cold Spring Harbor Laboratory; Istituto Europeo di Oncologia; Massachusetts Institute of Technology; Congressionally Directed Medical Research Programs; University of Manchester; Israel Cancer Association; United States - Israel Binational Science Foundation; Israel Cancer Research Fund","keywords":"Biology; Aneuploidy; Chromosome instability; Gene dosage; Gene; Genome instability; Genetics; Chromosome; Karyotype; Cancer; Cancer research; Copy-number variation; Mitosis; Genome; DNA damage; Gene expression; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007010056,0.0001704301,0.0001455818,0.00001222872,0.00007625942,0.00002950365,0.00009701219,0.000136487,0.0001182386],"category_scores_gemma":[0.00001076741,0.0001846451,0.00002563627,0.00008365614,0.00003697063,0.000003392656,0.0001422922,0.00006733487,0.00002135864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003784262,"about_ca_system_score_gemma":0.0001347111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001021186,"about_ca_topic_score_gemma":0.0002988233,"domain_scores_codex":[0.9990401,0.000031679,0.0001437381,0.0004563915,0.00009545793,0.0002326377],"domain_scores_gemma":[0.9995933,0.000005227476,0.00003444637,0.000180549,0.00006697635,0.0001195572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000497676,0.00008351015,0.006483573,0.00003035055,0.00002059682,0.000005263757,0.0001871476,5.945708e-8,0.9888426,0.000003604862,0.003340728,0.0009527827],"study_design_scores_gemma":[0.0005017452,0.00003650747,0.00392807,0.000006756306,0.000003884658,0.00001619784,0.0001054357,7.02717e-7,0.8793519,0.000004257371,0.1158198,0.0002247619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953773,0.0003866068,0.00006246314,0.0002965416,0.00007193568,0.0001795967,0.0000694689,0.00001107986,0.003544981],"genre_scores_gemma":[0.9893922,0.000380671,0.004212134,0.002367673,0.00004985537,0.00002882881,0.0003914302,0.00002621137,0.003151063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1124791,"threshold_uncertainty_score":0.7529609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007862048779378135,"score_gpt":0.2213805446523018,"score_spread":0.2135184958729237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}