{"id":"W3187516960","doi":"10.1016/j.devcel.2021.07.006","title":"Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy","year":2021,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":197,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Instituto Mexicano del Petróleo; Azrieli Foundation; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Ministero dell’Istruzione, dell’Università e della Ricerca; Human Frontier Science Program; Ministero della Salute; Fondazione Cariplo; Università degli Studi di Milano; Centre National de la Recherche Scientifique; Cold Spring Harbor Laboratory; Istituto Europeo di Oncologia; Massachusetts Institute of Technology; Congressionally Directed Medical Research Programs; University of Manchester; Israel Cancer Association; United States - Israel Binational Science Foundation; Israel Cancer Research Fund","keywords":"Biology; Aneuploidy; Chromosome instability; Gene dosage; Gene; Genome instability; Genetics; Chromosome; Karyotype; Cancer; Cancer research; Copy-number variation; Mitosis; Genome; DNA damage; Gene expression; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001765772,0.0003080008,0.0004325635,0.000688219,0.000196238,0.0004343116,0.0002551037,0.0004145911,0.003067538],"category_scores_gemma":[0.0005760561,0.0002863655,0.0002683096,0.0003802296,0.0003092407,0.0003198528,0.0003608285,0.0007779541,0.0003782327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004310478,"about_ca_system_score_gemma":0.0001830603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007883106,"about_ca_topic_score_gemma":0.000776141,"domain_scores_codex":[0.9997332,0.00005933364,0.00003205538,0.00002966763,0.00007602463,0.00006978482],"domain_scores_gemma":[0.9995528,0.0001684971,0.0001028069,0.00005804219,0.0000316929,0.00008607245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002058038,0.00003680497,0.0003453585,0.000008573458,0.00000444555,0.00009583344,0.00001288783,0.000117549,0.998389,0.0001286302,0.00002485343,0.0006303305],"study_design_scores_gemma":[0.00004663187,0.0006940535,0.02799622,0.000007605825,0.00002946242,0.001215286,0.0000851179,0.003957365,0.9641822,0.0002379617,0.00152952,0.00001859381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971592,0.0003447523,0.0008051268,0.00009610679,0.0000142284,0.0000241036,0.0001860385,0.00005480257,0.001315534],"genre_scores_gemma":[0.9985263,0.0001437613,0.0002551317,0.00001665177,0.000004703495,0.00001035504,0.0001463965,0.00001236844,0.0008841825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003067538,"threshold_uncertainty_score":0.01026189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007862048779378135,"score_gpt":0.2213805446523018,"score_spread":0.2135184958729237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}