{"id":"W3187608952","doi":"10.3390/nano11081984","title":"Targeting Intracellular Mycobacteria Using Nanosized Niosomes Loaded with Antibacterial Agents","year":2021,"lang":"en","type":"article","venue":"Nanomaterials","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"British Columbia Lung Association; Joint Programming Initiative on Antimicrobial Resistance","keywords":"Intracellular; Niosome; Cytotoxicity; Microbiology; Intracellular parasite; Macrophage; Secretion; Cytoplasm; Drug delivery; Antimicrobial; MTT assay; Mycobacterium; Biology; Chemistry; Cell; Cell biology; Vesicle; Bacteria; Membrane; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005348232,0.0004417877,0.0006623304,0.0000876653,0.0004022591,0.0001309839,0.0003032011,0.000410754,0.01171544],"category_scores_gemma":[0.0001045194,0.0004134971,0.00009556763,0.0002397712,0.0002089963,0.0003923294,0.0001609895,0.0002744793,0.00017218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001220129,"about_ca_system_score_gemma":0.0002298143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001061999,"about_ca_topic_score_gemma":0.000001329423,"domain_scores_codex":[0.9965663,0.00098089,0.0007497637,0.0006360004,0.0002691882,0.000797852],"domain_scores_gemma":[0.9987682,0.0001580745,0.0003318842,0.000318308,0.0002047015,0.000218876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001195894,0.0002703375,0.002061275,0.0001334193,0.0003366164,0.0007471314,0.0003355022,0.0005040084,0.9935779,0.00006727216,0.0003428389,0.0004278203],"study_design_scores_gemma":[0.003775704,0.00007367326,0.0003610362,0.00006420196,0.0002475524,0.000142214,0.00009640243,0.0003052948,0.9529462,0.00004331152,0.04144287,0.0005014831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904113,0.0004758152,0.0007452323,0.0001050239,0.0070267,0.0005156352,0.0002524898,0.0001792069,0.0002885304],"genre_scores_gemma":[0.9928786,0.0003091105,0.004170101,0.000785476,0.0009953483,0.00003373185,0.0003288374,0.00008501616,0.0004138475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04110004,"threshold_uncertainty_score":0.9998317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09338601543755823,"score_gpt":0.3976611931016965,"score_spread":0.3042751776641383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}