{"id":"W3187612437","doi":"10.7554/elife.68346.sa1","title":"Decision letter: Structurally distributed surface sites tune allosteric regulation","year":2021,"lang":"en","type":"peer-review","venue":"","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Allosteric regulation; Saturated mutagenesis; Dihydrofolate reductase; Mutagenesis; Mutation; Small molecule; Surface protein; Computational biology; Biophysics; Directed evolution; Biology; Chemistry; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004820607,0.0009576671,0.001465495,0.0009247582,0.00354386,0.005855285,0.003028224,0.01036425,0.2487851],"category_scores_gemma":[0.02329914,0.001604465,0.001050938,0.001163009,0.001364303,0.00300584,0.002538752,0.007094662,0.1546949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003251868,"about_ca_system_score_gemma":0.005539639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0023542,"about_ca_topic_score_gemma":0.00509747,"domain_scores_codex":[0.9945139,0.0006792036,0.0004773338,0.0005936069,0.002670193,0.001065785],"domain_scores_gemma":[0.9896334,0.00264941,0.0005391879,0.001336297,0.003570452,0.002271288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002777656,0.00007519241,0.0002286643,0.0001035632,0.000008764117,0.0001574723,0.0000294216,0.0002064677,0.001535353,0.005510751,0.9743112,0.01755539],"study_design_scores_gemma":[0.0002193521,0.00007006477,0.0004831616,0.0001254653,0.00001417602,0.0001515577,0.0001049933,0.00107324,0.007568074,0.00768636,0.9824567,0.00004707287],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.01150297,0.002216455,0.02589486,0.3677708,0.2181171,0.001271316,0.04440868,0.009684034,0.3191339],"genre_scores_gemma":[0.09606806,0.006147725,0.06646781,0.2434934,0.04289975,0.002328872,0.04143874,0.005849499,0.4953062],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.2487851,"threshold_uncertainty_score":0.832269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212108965187162,"score_gpt":0.3119049760421638,"score_spread":0.2997838863902921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}