{"id":"W3187662580","doi":"10.1101/2021.07.31.454588","title":"The immediate early protein 1 of human herpesvirus 6B counteracts ATM activation in an NBS1-dependent manner","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Genome instability; Biology; DNA damage; Telomere; Nijmegen breakage syndrome; Rad50; Cell biology; DNA repair; SAMHD1; DNA replication; DNA; Genetics; DNA-binding protein; Gene; Transcription factor; Ataxia-telangiectasia; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128781,0.0002742083,0.0001918565,0.0001584979,0.0001195741,0.0002745253,0.0002513816,0.0002013431,0.001640865],"category_scores_gemma":[0.0001088619,0.0001262773,0.0001927495,0.00006747594,0.0001550294,0.0001302182,0.0001880809,0.000489064,0.000450704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002105136,"about_ca_system_score_gemma":0.0001395107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002327161,"about_ca_topic_score_gemma":0.0003494846,"domain_scores_codex":[0.9998714,0.00002123982,0.00001100607,0.00002773133,0.00003694978,0.00003171419],"domain_scores_gemma":[0.9999105,0.00001351698,0.00002495928,0.00001218616,0.0000106177,0.00002829604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008252305,0.00003823125,0.0001009869,0.00003145395,0.000005337846,0.00001282552,0.00000434353,0.00002538407,0.9989998,0.00006497149,0.00003765095,0.0005964562],"study_design_scores_gemma":[0.00001781863,0.000258149,0.003127193,0.000008134728,0.00001072682,0.0001657028,0.00001239047,0.0007351856,0.9929893,0.0000381083,0.00263476,0.000002412212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942679,0.002676639,0.00114921,0.00008544338,0.00006369652,0.00001999369,0.0002064094,0.00006259159,0.001468148],"genre_scores_gemma":[0.9953015,0.0007980781,0.000901824,0.00005840961,0.000015365,0.00002757486,0.0005725024,0.00001356916,0.002311307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001640865,"threshold_uncertainty_score":0.00548923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02619659148374538,"score_gpt":0.2887127843376774,"score_spread":0.2625161928539321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}