{"id":"W3187759307","doi":"10.3390/cells10081983","title":"Effects of Reactive Oxygen and Nitrogen Species on TrkA Expression and Signalling: Implications for proNGF in Aging and Alzheimer’s Disease","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Basal forebrain; Tropomyosin receptor kinase A; Neurotrophin; Nerve growth factor; Biology; Low-affinity nerve growth factor receptor; Cell biology; Neurodegeneration; Brain-derived neurotrophic factor; Neuroscience; Neurotrophic factors; Internal medicine; Receptor; Cholinergic; Biochemistry; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003787995,0.0005183047,0.0004537931,0.0004236058,0.0002497809,0.0005552389,0.0003883368,0.0006949751,0.0009111488],"category_scores_gemma":[0.0002633952,0.0001194988,0.0004557597,0.0001872769,0.0005154172,0.0007195817,0.000358539,0.0006830498,0.0001925498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005590216,"about_ca_system_score_gemma":0.0003330949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00114948,"about_ca_topic_score_gemma":0.001270719,"domain_scores_codex":[0.9998621,0.00002795223,0.00001539239,0.00003195762,0.00003057671,0.00003194117],"domain_scores_gemma":[0.99975,0.00003479698,0.0000928446,0.00001035003,0.00006251228,0.00004946162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00313896,0.0004613102,0.008822849,0.005068104,0.0002641342,0.003678635,0.0008446352,0.0007251919,0.8002638,0.006608062,0.00335504,0.1667692],"study_design_scores_gemma":[0.0003364754,0.009181571,0.3080478,0.002287189,0.001323408,0.01233444,0.003676213,0.003545844,0.4283673,0.03219818,0.1984065,0.0002951942],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2662968,0.719683,0.003544542,0.003956933,0.0007675277,0.0000431898,0.0002391207,0.00008284258,0.005385967],"genre_scores_gemma":[0.7010401,0.2883215,0.00246059,0.001408531,0.0005727225,0.00006570311,0.0002392734,0.00001434036,0.005877212],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00114948,"threshold_uncertainty_score":0.004055977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08307872701830991,"score_gpt":0.3379150301783107,"score_spread":0.2548363031600008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}