{"id":"W3187797652","doi":"10.1039/d1fo01272j","title":"<i>Sargassum fusiforme</i> fucoidan alleviates diet-induced insulin resistance by inhibiting colon-derived ceramide biosynthesis","year":2021,"lang":"en","type":"article","venue":"Food & Function","topic":"Seaweed-derived Bioactive Compounds","field":"Agricultural and Biological Sciences","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Northern British Columbia","funders":"Science and Technology Plan Project of Wenzhou, China; National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Fucoidan; Ceramide; Sargassum; Insulin resistance; Chemistry; Biosynthesis; Biochemistry; Biology; Endocrinology; Insulin; Polysaccharide; Botany; Gene; Algae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009572048,0.0004502587,0.0002524747,0.0003316417,0.0001617434,0.0001759062,0.0001523907,0.0002775547,0.001691798],"category_scores_gemma":[0.00006872721,0.0001083176,0.0002583064,0.0001895147,0.0002515482,0.0002362324,0.0001448127,0.0006796925,0.0002066787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002932512,"about_ca_system_score_gemma":0.0002036232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001426352,"about_ca_topic_score_gemma":0.001623739,"domain_scores_codex":[0.9999436,0.000007952922,0.000005460008,0.00001022069,0.00001087695,0.00002188569],"domain_scores_gemma":[0.9999422,0.000003652773,0.00002214645,0.000004307385,0.000005698527,0.00002197624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001865248,0.0001079081,0.0002033011,0.00007349729,0.00002201897,0.00005052657,0.00001027315,0.00006799145,0.9932006,0.0001875982,0.0001728105,0.004038213],"study_design_scores_gemma":[0.0001567126,0.001832285,0.00641766,0.00001744331,0.00005769634,0.000229325,0.0000709495,0.00056165,0.9854885,0.0001473014,0.005010537,0.000009956126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925499,0.001604428,0.001993051,0.0004595946,0.00009271497,0.00003397,0.0008690016,0.0001884384,0.002208849],"genre_scores_gemma":[0.9941013,0.0008955669,0.001277021,0.0001435217,0.00001990148,0.0000278817,0.0006274009,0.00002063387,0.002886676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001691798,"threshold_uncertainty_score":0.00565958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01897845041078059,"score_gpt":0.1938401985532286,"score_spread":0.174861748142448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}