{"id":"W3187840688","doi":"10.1038/s41416-021-01432-8","title":"Mendelian randomisation study of smoking exposure in relation to breast cancer risk","year":2021,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval; Centre hospitalier universitaire de Québec; McGill University; University of Toronto; Royal Victoria Hospital; Queen's University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Medical Research and Materiel Command; Servicio Gallego de Salud; Instituto de Salud Carlos III; Medical Research Council; European Commission; Canadian Institutes of Health Research; Division of Cancer Prevention, National Cancer Institute; National Institutes of Health; Hellenic Health Foundation; Freistaat Sachsen; Deutschen Konsortium für Translationale Krebsforschung; Universitätsklinikum Hamburg-Eppendorf; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; National Institute for Health and Care Research; Centers for Disease Control and Prevention; Cancer Council South Australia; Memorial Sloan-Kettering Cancer Center; Centre International de Recherche sur le Cancer; Kreftforeningen; Institut National Du Cancer; Deutsche Krebshilfe; National Health and Medical Research Council; University of California, Irvine; Oulun Yliopisto; Cancer Institute NSW; Medizinischen Hochschule Hannover; Scottish Government; KWF Kankerbestrijding; Vetenskapsrådet; Norges Forskningsråd; Stockholms Läns Landsting; University of Westminster; Ligue Contre le Cancer; Kuopion Yliopistollinen Sairaala; University of Southern California; Cancerfonden; Cancer Council Tasmania; Itä-Suomen Yliopisto; Eberhard Karls Universität Tübingen; American Cancer Society; Cancer Australia; Russian Foundation for Basic Research; University of Crete; Institut National de la Santé et de la Recherche Médicale; Programme Grants for Applied Research; Robert Bosch Stiftung; Academy of Finland; Gentofte Hospital; King's College London; World Cancer Research Fund; Scottish Funding Council; University College London; Stavros Niarchos Foundation; Fondation de France; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Breast Cancer Campaign; National Cancer Institute; European Regional Development Fund; Ministerio de Sanidad, Servicios Sociales e Igualdad; University of Cambridge; Government of Canada; Fondation du cancer du sein du Québec; Génome Québec; National Breast Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; National Institute of Environmental Health Sciences; Swedish Cancer Foundation; Agency for Science, Technology and Research; Lon V. Smith Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; McGill University Health Centre; David F. and Margaret T. Grohne Family Foundation; Centre Hospitalier Universitaire de Québec; Genome Canada; Sundhed og Sygdom, Det Frie Forskningsråd; Deutsches Krebsforschungszentrum; Deutsche Gesetzliche Unfallversicherung; Deutsche Forschungsgemeinschaft; Breast Cancer Research Foundation; McGill University; Associazione Italiana per la Ricerca sul Cancro; Karolinska Institutet; Harvard T.H. Chan School of Public Health; Ministry of Science and Higher Education of the Russian Federation; U.S. Army; Université Laval; Agence Nationale de la Recherche; Wellcome Trust; Cancer Council Victoria; California Department of Public Health; Brigham and Women's Hospital; Rheinische Friedrich-Wilhelms-Universität Bonn; Oak Foundation; Cancer Research UK; Beckman Research Institute, City of Hope; Cancer Council NSW; Susan G. Komen for the Cure; U.S. Department of Health and Human Services; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; Fonds Wetenschappelijk Onderzoek","keywords":"Breast cancer; Medicine; Oncology; Mendelian randomization; Cancer; Internal medicine; Genetics; Biology; Genotype; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04048593,0.001139862,0.001896339,0.001413887,0.0007221127,0.0008915191,0.001633192,0.001503944,0.004238813],"category_scores_gemma":[0.09390096,0.0007019225,0.00191892,0.002038064,0.001197269,0.0006485664,0.0006936088,0.00125092,0.0005128217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000953153,"about_ca_system_score_gemma":0.001116611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0033253,"about_ca_topic_score_gemma":0.002023686,"domain_scores_codex":[0.9364694,0.05325159,0.002249944,0.004369233,0.002879368,0.000780442],"domain_scores_gemma":[0.958109,0.02623039,0.004262231,0.00993245,0.001092456,0.0003735219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07315382,0.001200199,0.6828197,0.002483119,0.02963273,0.005457399,0.002424804,0.01600969,0.01248581,0.04598247,0.008143953,0.1202064],"study_design_scores_gemma":[0.04101329,0.03032014,0.5556501,0.001001557,0.02818906,0.01797484,0.0007873536,0.1647322,0.009958168,0.1105895,0.03917383,0.0006099349],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6826131,0.006228037,0.293207,0.00119017,0.0006308134,0.008998535,0.002381162,0.0006198522,0.004131324],"genre_scores_gemma":[0.9368767,0.0008233234,0.05215489,0.0004780793,0.0001275978,0.006071875,0.0009972266,0.00008991261,0.002380399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04048593,"threshold_uncertainty_score":0.2141126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101237990433272,"score_gpt":0.2830393786920389,"score_spread":0.2729155796487117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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