{"id":"W3187855582","doi":"10.1073/pnas.2111313118","title":"Using a synthetic switch to regulate insulin receptor activation","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Insulin receptor; Insulin; Synthetic biology; Receptor; Cell biology; Chemistry; Computational biology; Biology; Biochemistry; Endocrinology; Insulin resistance","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004246178,0.0004392409,0.0003080422,0.0002850784,0.0002091597,0.000817604,0.0006157306,0.0005512115,0.004333647],"category_scores_gemma":[0.0005615213,0.0002492076,0.000355182,0.0002492525,0.0004731746,0.0006696063,0.0005213291,0.001295959,0.001588773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004331717,"about_ca_system_score_gemma":0.0001466143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001831167,"about_ca_topic_score_gemma":0.0002804026,"domain_scores_codex":[0.9996749,0.00003793375,0.00002424296,0.0001050968,0.000103466,0.00005439814],"domain_scores_gemma":[0.9998247,0.0000547706,0.00004993402,0.00001978228,0.00001952301,0.00003128912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003442024,0.00009399297,0.0001653982,0.0002630794,0.00002333132,0.0001616272,0.00006979011,0.0003288053,0.969748,0.008231062,0.001914572,0.01865625],"study_design_scores_gemma":[0.0001119059,0.0007599393,0.0006144147,0.00004163272,0.00003532878,0.0004498494,0.00004953428,0.002431189,0.8634806,0.00179393,0.130185,0.00004672378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6638964,0.0490679,0.167643,0.005432049,0.009354518,0.0005795565,0.002946289,0.005733952,0.09534633],"genre_scores_gemma":[0.9158518,0.01258363,0.04505688,0.002441103,0.0005085476,0.0003752346,0.0009991628,0.0004084542,0.02177525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004333647,"threshold_uncertainty_score":0.01449746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03053733658066153,"score_gpt":0.3036450939817014,"score_spread":0.2731077574010398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}