{"id":"W3187983240","doi":"10.1016/j.parkreldis.2021.08.001","title":"Variable expression of mitochondrial complex IV in the course of nigral intracellular accumulation of α-synuclein","year":2021,"lang":"en","type":"article","venue":"Parkinsonism & Related Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"","keywords":"Substantia nigra; Pathology; Parkinson's disease; Pathogenesis; Lewy body; Synuclein; Pathological; Mitochondrion; Immunohistochemistry; Biology; Alpha-synuclein; Neuroscience; Disease; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236437,0.00009137847,0.000161077,0.0003882861,0.0001723114,0.0003043169,0.0001244993,0.0002448633,0.0007941115],"category_scores_gemma":[0.0002783485,0.0001069556,0.0001466328,0.0002144099,0.0002160079,0.0002207707,0.0001743316,0.0004031526,0.0001589998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002307622,"about_ca_system_score_gemma":0.0001232067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008693148,"about_ca_topic_score_gemma":0.001161615,"domain_scores_codex":[0.9999331,0.00000893484,0.000005392425,0.00001906688,0.00001342467,0.00002001434],"domain_scores_gemma":[0.9998215,0.00002185739,0.00005981256,0.0000105563,0.00004073447,0.00004552287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002352075,0.00004345046,0.04044176,0.00004566851,0.0000416852,0.001257661,0.0002126988,0.0001104922,0.9502645,0.0001777199,0.00007747285,0.004974829],"study_design_scores_gemma":[0.00003094102,0.0008474882,0.8300846,0.00001942612,0.00009718414,0.003975552,0.0007002358,0.0009843344,0.1615359,0.0005274609,0.001178155,0.0000187931],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978138,0.0008415196,0.0005767035,0.00002742907,0.000008226469,0.000005137399,0.00009438078,0.00001248824,0.0006202678],"genre_scores_gemma":[0.9986852,0.0002503791,0.0001980357,0.00001086708,0.000004616164,0.000005361563,0.0001290926,0.000003945016,0.0007124253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008693148,"threshold_uncertainty_score":0.002656579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02666714882471851,"score_gpt":0.2937969619799224,"score_spread":0.267129813155204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}