{"id":"W3188003094","doi":"10.1097/ju.0000000000002058.02","title":"PD44-02 PHARMACOGENOMIC DETERMINANTS OF SERUM STEROID HORMONE RESPONSES TO ABIRATERONE OR ENZALUTAMIDE AND HSD3B1 GENE MUTATION IN CRPC PATIENTS","year":2021,"lang":"en","type":"article","venue":"The Journal of Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Enzalutamide; Medicine; Abiraterone acetate; Abiraterone; Oncology; Pharmacogenomics; Pharmacogenetics; Prostate cancer; Internal medicine; Pharmacology; Cancer; Bioinformatics; Genotype; Gene; Genetics; Androgen deprivation therapy; Biology; Androgen receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002358208,0.0001512333,0.000232681,0.0003989202,0.0001994197,0.0005410791,0.0001706038,0.0003100427,0.008053584],"category_scores_gemma":[0.001093628,0.0001208673,0.0003253632,0.0007540855,0.0001009855,0.0001648375,0.000224852,0.0004997968,0.000995884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002676724,"about_ca_system_score_gemma":0.0002978733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001326434,"about_ca_topic_score_gemma":0.00150004,"domain_scores_codex":[0.9998405,0.00003386953,0.00001633026,0.00003069572,0.00005229232,0.00002629027],"domain_scores_gemma":[0.9992655,0.0001617695,0.000236586,0.0000386328,0.0001204246,0.0001771376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003100523,0.0002066862,0.9442537,0.00009590556,0.0002089678,0.0003113302,0.0000511233,0.0003096596,0.004054918,0.0001634584,0.007418195,0.03982564],"study_design_scores_gemma":[0.0001202199,0.0004637845,0.9936157,0.00001687989,0.00007410873,0.0007708032,0.00004457229,0.0003961116,0.0007071497,0.0001264145,0.00365403,0.00001023056],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892727,0.001530959,0.0002350411,0.0005277058,0.0000584992,0.00004540906,0.004935862,0.00004368387,0.00335014],"genre_scores_gemma":[0.9933243,0.0004364287,0.0003072018,0.0002135526,0.00007048325,0.00004386458,0.00312696,0.00001275436,0.002464538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008053584,"threshold_uncertainty_score":0.0269419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03465547636685034,"score_gpt":0.3462671067024123,"score_spread":0.3116116303355619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}