{"id":"W3188141723","doi":"10.1007/s00125-021-05523-2","title":"Simplifying prediction of disease progression in pre-symptomatic type 1 diabetes using a single blood sample","year":2021,"lang":"en","type":"article","venue":"Diabetologia","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; Lunds Universitet; National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; National Institute of Allergy and Infectious Diseases; Leona M. and Harry B. Helmsley Charitable Trust; National Health and Medical Research Council; National Institutes of Health; Diabetes-Stiftung; Bundesministerium für Bildung und Forschung; Juvenile Diabetes Research Foundation United States of America; Juvenile Diabetes Research Foundation International","keywords":"Medicine; Type 2 diabetes; Type 1 diabetes; Internal medicine; Diabetes mellitus; Population; Blood sampling; Receiver operating characteristic; Disease; Area under the curve; Proportional hazards model; Ketoacidosis; Oncology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125284,0.0001294276,0.0002067521,0.00004861375,0.00004263782,0.00001946446,0.00009580411,0.0001304596,0.00001745559],"category_scores_gemma":[0.0007549967,0.0001280805,0.00007234465,0.0002638905,0.00005415493,0.0000078037,0.0001068885,0.0000661767,7.765854e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001525432,"about_ca_system_score_gemma":0.0001009415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007203157,"about_ca_topic_score_gemma":0.00000878122,"domain_scores_codex":[0.9989393,0.0000923948,0.0002604167,0.0002894088,0.0001158165,0.000302715],"domain_scores_gemma":[0.999424,0.0000425571,0.0001273755,0.0002347135,0.0001014839,0.00006987336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001422415,0.0003467423,0.5871788,0.00008337225,0.00004973835,0.000001706792,0.00002716048,0.0002417238,0.4106467,0.000008432046,0.00003467252,0.001366712],"study_design_scores_gemma":[0.001609741,0.0006124929,0.3433458,0.0004620788,0.0002016428,7.267755e-7,0.0001459374,0.004278197,0.6478253,0.0007501366,0.0003874462,0.000380548],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971585,0.002301899,0.00007739419,0.00002700999,0.0001217847,0.0001484172,0.00007924885,0.00001881998,0.00006688393],"genre_scores_gemma":[0.998328,0.00006135421,0.001039541,0.00006634492,0.00003322749,0.00001559701,0.0004257646,0.00001788398,0.00001228758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.243833,"threshold_uncertainty_score":0.522297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462763222659749,"score_gpt":0.2586546696879626,"score_spread":0.2440270374613651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}