{"id":"W3188141723","doi":"10.1007/s00125-021-05523-2","title":"Simplifying prediction of disease progression in pre-symptomatic type 1 diabetes using a single blood sample","year":2021,"lang":"en","type":"article","venue":"Diabetologia","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; Lunds Universitet; National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; National Institute of Allergy and Infectious Diseases; Leona M. and Harry B. Helmsley Charitable Trust; National Health and Medical Research Council; National Institutes of Health; Diabetes-Stiftung; Bundesministerium für Bildung und Forschung; Juvenile Diabetes Research Foundation United States of America; Juvenile Diabetes Research Foundation International","keywords":"Medicine; Type 2 diabetes; Type 1 diabetes; Internal medicine; Diabetes mellitus; Population; Blood sampling; Receiver operating characteristic; Disease; Area under the curve; Proportional hazards model; Ketoacidosis; Oncology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01052139,0.001721149,0.001334067,0.001458782,0.0003491181,0.001902253,0.0009010028,0.001033882,0.001056228],"category_scores_gemma":[0.020129,0.0004631529,0.001608832,0.0008452346,0.0005581232,0.001061454,0.001028182,0.001706289,0.0004428603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006274518,"about_ca_system_score_gemma":0.001084424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00597224,"about_ca_topic_score_gemma":0.00614527,"domain_scores_codex":[0.9960024,0.002440288,0.0001974864,0.0006749357,0.00049744,0.0001874638],"domain_scores_gemma":[0.9803885,0.01405424,0.002850188,0.001211315,0.0009571896,0.0005385632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004021313,0.0005443986,0.8102332,0.0002506006,0.001167896,0.0001917812,0.0001588632,0.1003819,0.0022375,0.0005771691,0.001761453,0.07847389],"study_design_scores_gemma":[0.0002001552,0.002087275,0.213156,0.0001225001,0.000559576,0.0004793984,0.00009423166,0.7766544,0.002263605,0.003346208,0.000932022,0.0001046205],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8851733,0.002943823,0.1067203,0.0007994204,0.0001774184,0.0002218675,0.001330771,0.0008193699,0.0018137],"genre_scores_gemma":[0.9856177,0.0002781079,0.01288355,0.0001089237,0.00007418307,0.00004830104,0.0005912067,0.00002666892,0.0003714488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01052139,"threshold_uncertainty_score":0.05564314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462763222659749,"score_gpt":0.2586546696879626,"score_spread":0.2440270374613651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}