{"id":"W3188154232","doi":"10.3389/fcell.2021.714710","title":"The Nitric Oxide Donor, S-Nitrosoglutathione, Rescues Peroxisome Number and Activity Defects in PEX1G843D Mild Zellweger Syndrome Fibroblasts","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton; Dalhousie University; University of Alberta","funders":"Canadian Institutes of Health Research; Dalhousie University; University of Alberta; Women and Children's Health Research Institute; Children's Health Research Institute; Alberta Innovates; McGill University; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Zellweger syndrome; Peroxisome; Nitric oxide; Peroxisomal disorder; Medicine; Biology; Pharmacology; Cancer research; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354026,0.000387113,0.0003541592,0.0002360478,0.0001282647,0.0001958744,0.0002230747,0.0003198558,0.0006985345],"category_scores_gemma":[0.00009462534,0.0001107421,0.0002901409,0.000135915,0.0001350543,0.00008972835,0.0001756089,0.0004027007,0.0002148187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001707576,"about_ca_system_score_gemma":0.0002814509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001563945,"about_ca_topic_score_gemma":0.00286401,"domain_scores_codex":[0.9998885,0.00001328885,0.00001481088,0.00002219542,0.00004597936,0.000015132],"domain_scores_gemma":[0.9999238,0.00001539261,0.00001854074,0.000008865961,0.000009800537,0.00002352956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001049746,0.00003764459,0.0001154055,0.00003168439,0.00000724475,0.00009119679,0.00000511989,0.00008310819,0.9977608,0.00002885999,0.00005519798,0.00167872],"study_design_scores_gemma":[0.0000606972,0.0009143524,0.003682799,0.000008310066,0.00003526025,0.0003439231,0.00003081372,0.001004876,0.9902517,0.00004640485,0.003613605,0.000007291577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917453,0.002563542,0.002567784,0.0001642736,0.00006477431,0.00005544833,0.0008699656,0.0001818072,0.001787083],"genre_scores_gemma":[0.9914162,0.001759599,0.002094013,0.00009679327,0.000009145192,0.0000393718,0.001054945,0.00002624837,0.003503702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001563945,"threshold_uncertainty_score":0.003109753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005564823068225517,"score_gpt":0.2127385434619715,"score_spread":0.207173720393746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}