{"id":"W3188214322","doi":"10.1093/jac/dkab292","title":"Aztreonam/avibactam effect on pharmacodynamic indices for mutant selection of<i>Escherichia coli and Klebsiella pneumoniae</i>harbouring serine- and New Delhi metallo-β-lactamases","year":2021,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Science Foundation of Shandong Province","keywords":"Klebsiella pneumoniae; Aztreonam; Escherichia coli; Microbiology; Pharmacodynamics; Serine; Ceftazidime/avibactam; Enterobacteriaceae; Chemistry; Biology; Antibiotics; Antibiotic resistance; Pharmacokinetics; Pharmacology; Biochemistry; Gene; Imipenem","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002335031,0.0002505783,0.000285766,0.0001294584,0.00007883969,0.000227328,0.0001526169,0.0002487475,0.0005437544],"category_scores_gemma":[0.0009459245,0.00009819731,0.0003639329,0.0001139106,0.0001356051,0.0001450262,0.0001178305,0.000224786,0.00009554029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002940356,"about_ca_system_score_gemma":0.0002152111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001152865,"about_ca_topic_score_gemma":0.0006394967,"domain_scores_codex":[0.9998945,0.00003191407,0.000009711194,0.00002148568,0.00002275985,0.00001967306],"domain_scores_gemma":[0.9995323,0.0002464795,0.00009101373,0.00003634906,0.00005762993,0.00003617898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002640913,0.0004413353,0.04203435,0.000254923,0.0002699999,0.0002400361,0.00009478058,0.2459026,0.6851745,0.0003320212,0.0002495496,0.02236494],"study_design_scores_gemma":[0.0001017476,0.005350637,0.06003969,0.00002630357,0.0002194912,0.0004767213,0.000101945,0.5065324,0.4259522,0.0001990995,0.0009488302,0.00005079293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980286,0.0001799634,0.001431913,0.00001783336,0.000002713856,0.000005004014,0.00007188432,0.00003141505,0.0002305424],"genre_scores_gemma":[0.9993081,0.0000510397,0.0005080228,0.000005827085,8.421326e-7,0.000004492143,0.00006413656,0.000004269265,0.00005323313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152865,"threshold_uncertainty_score":0.002292335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007134290252246541,"score_gpt":0.2552639278348915,"score_spread":0.248129637582645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}