{"id":"W3188233590","doi":"10.1136/annrheumdis-2021-220043","title":"Preclinical models of arthritis for studying immunotherapy and immune tolerance","year":2021,"lang":"en","type":"review","venue":"Annals of the Rheumatic Diseases","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Janssen Biotech; Arthritis Queensland; China Medical University Hospital; Innovative Medicines Initiative; Universität Wien; Juvenile Diabetes Research Foundation Australia; National Health and Medical Research Council; Medizinische Universität Wien; European Commission; European Federation of Pharmaceutical Industries and Associations; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Medicine; Autoimmunity; Disease; Arthritis; Immunotherapy; Immunology; Rheumatoid arthritis; Immune system; Autoimmune disease; Autoantibody; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001052831,0.001303475,0.001396598,0.001848231,0.0002642479,0.001007008,0.001201375,0.00140875,0.00422906],"category_scores_gemma":[0.0006905842,0.0003092752,0.0006292807,0.001118755,0.0008450505,0.001489905,0.000756678,0.003246506,0.00303291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008199426,"about_ca_system_score_gemma":0.001102575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006132819,"about_ca_topic_score_gemma":0.0009275489,"domain_scores_codex":[0.9996551,0.00009364997,0.00003631067,0.00004244026,0.0001407033,0.00003174866],"domain_scores_gemma":[0.9996356,0.0001681311,0.00004645882,0.00002693003,0.00008224548,0.00004064308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001570014,0.0002830494,0.000301749,0.02347223,0.0001058533,0.0004369301,0.0001056128,0.000760684,0.03028077,0.02437701,0.07151369,0.8482055],"study_design_scores_gemma":[0.00002008948,0.0001734612,0.0004335346,0.001854034,0.00006071133,0.0009938122,0.0000298367,0.00008090187,0.002397265,0.003016778,0.9909235,0.00001608779],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000232361,0.9932249,0.001106297,0.0005241956,0.0008672537,0.00003147634,0.00005106202,0.00003577618,0.003926707],"genre_scores_gemma":[0.001509032,0.9944165,0.001150835,0.0004465889,0.0003461668,0.00005697071,0.0001120233,0.000007546583,0.001954351],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00422906,"threshold_uncertainty_score":0.01414764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1114241084994259,"score_gpt":0.3568920645400439,"score_spread":0.245467956040618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}