{"id":"W3188273354","doi":"10.1016/j.jcyt.2021.06.003","title":"A biomarker-guided, prospective, phase 2 trial of pre-emptive graft-versus-host disease therapy using anti-thymocyte globulin","year":2021,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Health Services; University of Calgary","funders":"Alberta Innovates","keywords":"Medicine; Anti-thymocyte globulin; Internal medicine; Hazard ratio; Incidence (geometry); Graft-versus-host disease; Clinical endpoint; Gastroenterology; Prospective cohort study; Hematopoietic stem cell transplantation; Immunology; Cumulative incidence; Globulin; Randomized controlled trial; Transplantation; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001935568,0.002207611,0.002005123,0.000485043,0.0004422121,0.001871662,0.0008802073,0.001897018,0.00259564],"category_scores_gemma":[0.001175749,0.0004156695,0.001230344,0.0004279581,0.001342158,0.001217007,0.000478815,0.004094705,0.0007175595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001101624,"about_ca_system_score_gemma":0.001437375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005979058,"about_ca_topic_score_gemma":0.001510487,"domain_scores_codex":[0.9992981,0.0003368038,0.00002104867,0.000137679,0.00005820676,0.0001480523],"domain_scores_gemma":[0.9993131,0.0001620782,0.0001148879,0.00006702438,0.00003985906,0.000303065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8711784,0.03823673,0.005532739,0.000342614,0.001239992,0.0001728566,0.0001554479,0.001916862,0.0197058,0.0006864049,0.002699855,0.05813223],"study_design_scores_gemma":[0.6345832,0.3497266,0.007274501,0.00004104145,0.0005082655,0.0001733683,0.0000629209,0.001226855,0.003127323,0.0007538287,0.002481755,0.00004029603],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903077,0.002742725,0.0009343949,0.001111171,0.0003705787,0.001698682,0.0008709477,0.00009207172,0.001871667],"genre_scores_gemma":[0.9863814,0.001726465,0.002563633,0.002493332,0.0002978849,0.002209676,0.002032135,0.00003832576,0.002257276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00259564,"threshold_uncertainty_score":0.01023638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07376816231491407,"score_gpt":0.3794634805977141,"score_spread":0.3056953182828001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}