{"id":"W3188308472","doi":"10.1111/jcmm.16840","title":"The stressosome, a caspase‐8‐activating signalling complex assembled in response to cell stress in an ATG5‐mediated manner","year":2021,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"European Commission; Irish Research Council; Vetenskapsrådet; Science Foundation Ireland; Canada Research Chairs; Horizon 2020 Framework Programme; Irish Research Council for Science, Engineering and Technology","keywords":"FADD; Cell biology; Death domain; Programmed cell death; Unfolded protein response; Caspase; Caspase 10; Chemistry; Caspase 8; Endoplasmic reticulum; ATG5; Signal transducing adaptor protein; Biology; Signal transduction; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140864,0.0004377018,0.0002369877,0.0001754966,0.0002656578,0.0005340814,0.0002570829,0.0004924872,0.00155299],"category_scores_gemma":[0.0001179202,0.0002479725,0.0004382569,0.0001193608,0.0002389489,0.0004209601,0.0002339446,0.0002728582,0.0005314073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004496443,"about_ca_system_score_gemma":0.0002402914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004232012,"about_ca_topic_score_gemma":0.0002607947,"domain_scores_codex":[0.9999354,0.00001054356,0.000005241489,0.00001896855,0.00001744617,0.00001244377],"domain_scores_gemma":[0.9999572,0.000005467095,0.00001525479,0.00000387812,0.00000734918,0.00001077618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002624484,0.00003867829,0.001052206,0.0002294584,0.00006301343,0.0002925894,0.00004368453,0.009403851,0.9838118,0.001817505,0.0003127012,0.002672018],"study_design_scores_gemma":[0.0001300038,0.0003925059,0.005604299,0.00003572882,0.00008703686,0.0006705043,0.00009365749,0.1052359,0.8736303,0.002021956,0.01205217,0.00004592026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9601543,0.001305361,0.03523529,0.0001314179,0.0001051532,0.00008172552,0.0006150439,0.0004153166,0.001956317],"genre_scores_gemma":[0.9912661,0.0003454243,0.006288996,0.00002832753,0.000005571233,0.00002758104,0.0007480156,0.00002765848,0.001262343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00155299,"threshold_uncertainty_score":0.00519532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112333609458924,"score_gpt":0.2678107333208282,"score_spread":0.256687397226239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}