{"id":"W3188339835","doi":"10.1093/noajnl/vdab071.009","title":"BSCI-10. Invasive growth of brain metastases is driven by cancer cell-pSTAT3+ reactive astrocyte crosstalk","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill Genome Centre; McGill University; University of British Columbia; McGill University Health Centre","funders":"","keywords":"Cancer research; STAT3; Biology; Cell growth; In vivo; Medicine; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002383357,0.0004600225,0.0004482472,0.0003797908,0.0005175121,0.0008058436,0.0003114443,0.0004524081,0.005472484],"category_scores_gemma":[0.0002234345,0.0003201432,0.0004373988,0.0004660906,0.0003060805,0.0002330403,0.0003896323,0.001405391,0.002649756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008383452,"about_ca_system_score_gemma":0.0006964855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004412595,"about_ca_topic_score_gemma":0.007885696,"domain_scores_codex":[0.9995461,0.00002255632,0.00002210215,0.0001062198,0.0001910246,0.0001120956],"domain_scores_gemma":[0.9997944,0.00002072868,0.00004234384,0.00002066887,0.00004079226,0.00008117014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003432653,0.000077595,0.001746202,0.0002313108,0.00002205764,0.0001019776,0.00004959941,0.000315321,0.9887022,0.0003165935,0.002951004,0.005143011],"study_design_scores_gemma":[0.00008793718,0.0005811126,0.04170264,0.00005545382,0.00008167136,0.0009095693,0.0002324008,0.007181201,0.9129243,0.0004159814,0.03579561,0.00003213528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9381039,0.00600474,0.008909767,0.0008844722,0.0003592182,0.0002166987,0.02790526,0.002877289,0.01473878],"genre_scores_gemma":[0.9472302,0.002050868,0.005688187,0.0005865356,0.00002406122,0.0002537524,0.03197415,0.0003298311,0.0118624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005472484,"threshold_uncertainty_score":0.01830727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01565399580894878,"score_gpt":0.3185097197140506,"score_spread":0.3028557239051018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}