{"id":"W3188441277","doi":"10.1503/cmaj.202456","title":"Performance of a universal prenatal screening program incorporating cell-free fetal DNA analysis in Ontario, Canada","year":2021,"lang":"en","type":"article","venue":"Canadian Medical Association Journal","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Toronto; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Cell-free fetal DNA; Medicine; Prenatal screening; Cohort; Population; Prenatal diagnosis; Down syndrome; Obstetrics; Retrospective cohort study; Cohort study; Pregnancy; False positive rate; Pediatrics; Family medicine; Fetus; Environmental health; Biology; Internal medicine; Genetics; Statistics; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001498357,0.000362961,0.0004055024,0.0008049345,0.002158315,0.000912959,0.001618586,0.0003620462,0.001226189],"category_scores_gemma":[0.006456778,0.0004438516,0.0005211575,0.002267921,0.0009574513,0.0003178998,0.001289949,0.0004312303,0.0001752777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.06316957,"about_ca_system_score_gemma":0.09125544,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9964225,"about_ca_topic_score_gemma":0.9972145,"domain_scores_codex":[0.9971698,0.0002468103,0.0001872945,0.0004180775,0.001212538,0.0007654798],"domain_scores_gemma":[0.9927088,0.0005765731,0.00139845,0.0002867363,0.003525735,0.001503755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001373895,0.0000488847,0.9860764,0.00009239348,0.00005289478,0.0001642367,0.001333253,0.0004971688,0.0003737257,0.0001387395,0.001759624,0.009325384],"study_design_scores_gemma":[0.00001365842,0.00007897981,0.9965482,0.00004597182,0.00002940368,0.00009086108,0.001004154,0.0007931989,0.000170985,0.00002548543,0.001184529,0.00001454275],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899197,0.0005083806,0.0003029413,0.0006090972,0.00001793507,0.0001612141,0.004924626,0.00005491162,0.003501182],"genre_scores_gemma":[0.9971143,0.0003353429,0.0004717404,0.0001381061,0.000005346456,0.00004378543,0.001163059,0.00001006206,0.0007183097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06316957,"threshold_uncertainty_score":0.4583294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006554969969678351,"score_gpt":0.2054227740558328,"score_spread":0.1988678040861544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}