{"id":"W3188554627","doi":"10.1186/s13195-021-00872-x","title":"Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project","year":2021,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Traumatic Brain Injury Research","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute on Aging; Clinical and Translational Science Institute, Boston University; University of California, San Diego; National Institutes of Health; Grifols; Eisai; Genentech; University of Oxford; National Institute of Neurological Disorders and Stroke; University of Cambridge; Agios Pharmaceuticals; National Institute of General Medical Sciences; H. Lundbeck A/S; Sunovion; University of Washington; Patient-Centered Outcomes Research Institute; School of Medicine, Boston University; Eli Lilly and Company; U.S. Department of Defense; George Washington University; Allergan; National Operating Committee on Standards for Athletic Equipment; York University; Pfizer; Biogen; Novo Nordisk; Massachusetts General Hospital; National Collegiate Athletic Association; Cleveland Clinic; Brigham and Women's Hospital; Amgen","keywords":"Chronic traumatic encephalopathy; Medicine; Traumatic brain injury; Neuroimaging; Concussion; Neuropsychology; Physical therapy; Physical medicine and rehabilitation; Poison control; Psychiatry; Cognition; Emergency medicine; Injury prevention","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.03187246,0.0003453245,0.0007260504,0.0009319173,0.001471186,0.000337259,0.0005520313,0.0002355733,0.0001617105],"category_scores_gemma":[0.02063195,0.0002473396,0.0001198927,0.002355186,0.001028428,0.0002265032,0.0005260753,0.001466037,0.00002241255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002624049,"about_ca_system_score_gemma":0.004139845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002193623,"about_ca_topic_score_gemma":0.0001310701,"domain_scores_codex":[0.9834753,0.01147695,0.0006646385,0.001123826,0.001598925,0.001660342],"domain_scores_gemma":[0.9290649,0.06737062,0.00007094337,0.001038889,0.001900599,0.0005540298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002522956,0.0001465531,0.0003753855,0.0004767757,0.002072357,0.000156977,0.0109919,0.00001737631,0.0984136,0.001481642,0.0028397,0.8805048],"study_design_scores_gemma":[0.01455598,0.008128242,0.1064726,0.001266914,0.0003815537,0.001024069,0.01263205,0.003462506,0.7691783,0.02363004,0.0580151,0.001252745],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.3575202,0.291532,0.2790793,0.04569083,0.0002547421,0.02562856,0.00002527163,0.000152879,0.0001161617],"genre_scores_gemma":[0.09599444,0.03660233,0.8504283,0.0008206587,0.000692399,0.0148255,0.00001766179,0.0001808798,0.0004378738],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.879252,"threshold_uncertainty_score":0.9999979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7140558873293122,"score_gpt":0.5850251497549139,"score_spread":0.1290307375743983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}