{"id":"W3188911186","doi":"10.1093/mmy/myab042","title":"Complexing amphotericin B with gold nanoparticles improves fungal clearance from the brains of mice infected with Cryptococcal neoformans","year":2021,"lang":"en","type":"article","venue":"Medical Mycology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cytodiagnostics (Canada)","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; EMC; U.S. Department of Veterans Affairs","keywords":"Amphotericin B; Cryptococcus neoformans; Microbiology; Colloidal gold; Cryptococcal meningitis; Antifungal; Cryptococcosis; Mycosis; Medicine; Chemistry; Virology; Immunology; Biology; Nanoparticle; Nanotechnology; Materials science; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008242553,0.0003842538,0.0002452946,0.0001736594,0.0000887803,0.0001255412,0.000174519,0.0003532772,0.0005473412],"category_scores_gemma":[0.00008385814,0.0001582446,0.0001552036,0.00006895974,0.0001214083,0.0001789515,0.0001129078,0.0004425594,0.000141716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000123116,"about_ca_system_score_gemma":0.0001368256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009056717,"about_ca_topic_score_gemma":0.001076176,"domain_scores_codex":[0.9999429,0.000007682646,0.00000574282,0.00001481711,0.00001472799,0.00001409773],"domain_scores_gemma":[0.9999611,0.000004897613,0.00001025929,0.000002763575,0.000006463943,0.0000144931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001344385,0.00003767497,0.00003869806,0.00002671604,0.000003021902,0.00001446802,0.000008140662,0.00003706114,0.998409,0.00001146245,0.00003214537,0.001247183],"study_design_scores_gemma":[0.00002942488,0.001079839,0.001629922,0.000006552842,0.0000153658,0.00009876352,0.00001670019,0.001073909,0.9948956,0.00002793183,0.001120694,0.000005199493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961689,0.001071887,0.001503178,0.0001073237,0.00003912133,0.00002720819,0.00009737794,0.00008658834,0.0008984349],"genre_scores_gemma":[0.9917569,0.001069529,0.003357942,0.0001121632,0.00001289754,0.00005356421,0.0002115834,0.00002195252,0.003403469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009056717,"threshold_uncertainty_score":0.001831055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01255045407031422,"score_gpt":0.2518261029078343,"score_spread":0.2392756488375201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}