{"id":"W3188911186","doi":"10.1093/mmy/myab042","title":"Complexing amphotericin B with gold nanoparticles improves fungal clearance from the brains of mice infected with Cryptococcal neoformans","year":2021,"lang":"en","type":"article","venue":"Medical Mycology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cytodiagnostics (Canada)","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; EMC; U.S. Department of Veterans Affairs","keywords":"Amphotericin B; Cryptococcus neoformans; Microbiology; Colloidal gold; Cryptococcal meningitis; Antifungal; Cryptococcosis; Mycosis; Medicine; Chemistry; Virology; Immunology; Biology; Nanoparticle; Nanotechnology; Materials science; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001594529,0.0001448838,0.0004358598,0.00002963784,0.0001273018,0.00001007951,0.0000894764,0.0001100915,0.0003429984],"category_scores_gemma":[0.0004036536,0.00007732223,0.00005136827,0.0003582336,0.0006637549,0.00004111435,0.00008953879,0.0003700116,0.0000116869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003056881,"about_ca_system_score_gemma":0.0002560975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005337591,"about_ca_topic_score_gemma":0.001958219,"domain_scores_codex":[0.9987556,0.0001200869,0.0002805171,0.0002376364,0.0002941042,0.0003120078],"domain_scores_gemma":[0.9986882,0.0006831166,0.00008443935,0.0002258482,0.000184205,0.0001341655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002752583,0.00121539,0.3538847,0.000192292,0.001042407,0.000908105,0.002860523,0.0000287626,0.6203615,0.002253241,0.00546256,0.009037901],"study_design_scores_gemma":[0.003504103,0.002470326,0.9618182,0.0002991876,0.000203615,0.0005718495,0.001007981,0.0007492112,0.01992773,0.00007871754,0.009209534,0.0001595438],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920738,0.0003897295,0.0004043615,0.005481086,0.0001219685,0.0002474176,0.00001297867,0.00004981932,0.001218889],"genre_scores_gemma":[0.9960916,0.00007396485,0.0008376585,0.002655276,0.0001820321,0.00003930842,0.00001541176,0.00001535801,0.00008940409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6079335,"threshold_uncertainty_score":0.3755592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01255045407031422,"score_gpt":0.2518261029078343,"score_spread":0.2392756488375201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}