{"id":"W3189003104","doi":"10.20944/preprints202108.0137.v1","title":"A Candidate RNAi Screen Reveals Diverse RNA-Binding Protein Phenotypes in Drosophila Flight Muscle","year":2021,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Deutsche Gesellschaft für Muskelkranke; Deutsche Forschungsgemeinschaft; International Max Planck Research School for Environmental, Cellular and Molecular Microbiology","keywords":"Gene knockdown; Biology; Sarcomere; Phenotype; Alternative splicing; RNA splicing; RNA interference; Myogenesis; Cell biology; RNA-binding protein; Spliceosome; Gene isoform; Genetics; Myocyte; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001516373,0.0005097759,0.0003390472,0.000556294,0.0002475709,0.0002901031,0.0003008432,0.0003413382,0.001665803],"category_scores_gemma":[0.000103996,0.0002231966,0.0003896629,0.0002631836,0.0001797911,0.00008088622,0.0002042575,0.000357288,0.0005442877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003681856,"about_ca_system_score_gemma":0.0002164194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002552899,"about_ca_topic_score_gemma":0.007756344,"domain_scores_codex":[0.9998196,0.00001487761,0.0000229796,0.00006281132,0.00005843296,0.00002135155],"domain_scores_gemma":[0.9998719,0.00003453135,0.00003699536,0.00001248463,0.00001402269,0.00003014553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002701623,0.00001357952,0.0002189149,0.00003159677,0.00001042274,0.00009829003,0.00001260666,0.00006232003,0.9984028,0.00005477937,0.00007795227,0.0009897496],"study_design_scores_gemma":[0.00004854513,0.0002526536,0.03372402,0.00002402077,0.0001375857,0.0006788324,0.00006798745,0.004386633,0.9532964,0.00006465957,0.007295582,0.00002297994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783694,0.001095936,0.009218593,0.0001340428,0.0000351516,0.0001409791,0.007059054,0.0005744599,0.003372401],"genre_scores_gemma":[0.9678285,0.001074107,0.0121826,0.0002938765,0.000008782372,0.0001697962,0.008576819,0.0002796549,0.009585903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002552899,"threshold_uncertainty_score":0.005572677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05863373989834415,"score_gpt":0.3279696577481223,"score_spread":0.2693359178497782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}