{"id":"W3189005381","doi":"10.1080/15548627.2021.1956123","title":"Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca<sup>2+</sup>-PPP3/calcineurin-TFEB axis","year":2021,"lang":"en","type":"article","venue":"Autophagy","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Newcastle University; University of Oxford; Diabetes Research and Wellness Foundation; Lunds Universitet; Diabetes UK; University of Alberta; International Seafood Sustainability Foundation; Wellcome Trust; Wellcome","keywords":"Autophagy; TFEB; Calcineurin; Cell biology; Biology; NFAT; BAG3; mTORC1; Endocrinology; Islet; Internal medicine; Signal transduction; PI3K/AKT/mTOR pathway; Diabetes mellitus; Biochemistry; Transplantation; Medicine; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590788,0.0003803094,0.0003161218,0.0002201859,0.0001275963,0.0002758366,0.000139871,0.0001914054,0.0008778889],"category_scores_gemma":[0.00007314999,0.0001507953,0.0004309899,0.0001466263,0.0002162162,0.0002282774,0.0002320417,0.0005268854,0.0001965684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002548341,"about_ca_system_score_gemma":0.0001996596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002395486,"about_ca_topic_score_gemma":0.0003927407,"domain_scores_codex":[0.9999104,0.00001519098,0.00001208951,0.00002005252,0.00002053999,0.00002189517],"domain_scores_gemma":[0.9999422,0.00000867213,0.00002216617,0.000007215522,0.000004993787,0.00001479587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000469303,0.00002635555,0.0001609425,0.00004376751,0.000007012685,0.00007649812,0.000007287875,0.00005827795,0.9984252,0.00004323327,0.00002708249,0.0006549602],"study_design_scores_gemma":[0.0000531165,0.0003951366,0.009551911,0.00000638206,0.00002275647,0.0002856625,0.00002223943,0.000752497,0.987455,0.00006537349,0.001385127,0.000004899151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961435,0.00120083,0.001113689,0.000108218,0.00002429111,0.00001846312,0.0004277278,0.0000853005,0.000877987],"genre_scores_gemma":[0.9948441,0.0007396476,0.002049783,0.00007771051,0.00001472656,0.00005688616,0.0007025255,0.00002008846,0.001494545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008778889,"threshold_uncertainty_score":0.00293684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377223678803371,"score_gpt":0.2547223301785706,"score_spread":0.2409500933905369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}