{"id":"W3189005381","doi":"10.1080/15548627.2021.1956123","title":"Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca<sup>2+</sup>-PPP3/calcineurin-TFEB axis","year":2021,"lang":"en","type":"article","venue":"Autophagy","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Newcastle University; University of Oxford; Diabetes Research and Wellness Foundation; Lunds Universitet; Diabetes UK; University of Alberta; International Seafood Sustainability Foundation; Wellcome Trust; Wellcome","keywords":"Autophagy; TFEB; Calcineurin; Cell biology; Biology; NFAT; BAG3; mTORC1; Endocrinology; Islet; Internal medicine; Signal transduction; PI3K/AKT/mTOR pathway; Diabetes mellitus; Biochemistry; Transplantation; Medicine; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004690359,0.0005103489,0.0009970474,0.0002551875,0.000193105,0.00008461137,0.0002606802,0.0002635265,0.005634674],"category_scores_gemma":[0.0006740183,0.0003787057,0.0003473484,0.0009876438,0.0002049233,0.0001733779,0.0001602869,0.0005807625,0.001389048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001777898,"about_ca_system_score_gemma":0.0003239135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003305187,"about_ca_topic_score_gemma":0.00001252914,"domain_scores_codex":[0.9966279,0.0003074444,0.0008095991,0.0007931987,0.0005919472,0.0008698847],"domain_scores_gemma":[0.9971353,0.001018492,0.0001472434,0.00116524,0.0001864047,0.0003473525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002132529,0.00752429,0.08227431,0.00283641,0.003151842,0.0121109,0.01348132,0.02541647,0.6854402,0.004351617,0.1030342,0.05824581],"study_design_scores_gemma":[0.01696347,0.001225964,0.1274304,0.0008556859,0.001246098,0.0009450461,0.002376107,0.305898,0.4721042,0.002476939,0.06693286,0.001545222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983402,0.003851039,0.0002475646,0.002183127,0.0005642737,0.0006654941,0.0000253638,0.0002653211,0.008795877],"genre_scores_gemma":[0.9760925,0.000341425,0.0009202365,0.004560605,0.0004441611,0.00010114,0.0001015959,0.00008413255,0.01735421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2804815,"threshold_uncertainty_score":0.9998665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377223678803371,"score_gpt":0.2547223301785706,"score_spread":0.2409500933905369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}