{"id":"W3189118528","doi":"10.1055/s-0041-1723333","title":"Registrational phase 2 trial of sotorasib in KRAS p. G12C mutant NSCLC: first disclosure of the CodeBreaK 100 primary analysis","year":2021,"lang":"en","type":"article","venue":"Pneumologie","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"KRAS; Mutant; Phase (matter); Medicine; Internal medicine; Oncology; Chemistry; Genetics; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000137712,0.0001162348,0.0005495672,0.00006936894,0.00004860454,0.000004396817,0.0000833572,0.00005885067,0.0001146895],"category_scores_gemma":[0.0003185465,0.00006983964,0.0002908069,0.0006496179,0.0001559942,0.00002472756,0.00007527747,0.00009849053,6.145432e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001281992,"about_ca_system_score_gemma":0.0003742066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001959622,"about_ca_topic_score_gemma":0.001502268,"domain_scores_codex":[0.9989228,0.00006476142,0.0003805644,0.0002168763,0.0002809299,0.0001340142],"domain_scores_gemma":[0.9991706,0.0002033249,0.0001641235,0.0003106221,0.0001221581,0.0000291663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.063903,0.01107042,0.8795975,0.000447563,0.005946916,0.0007610469,0.001581626,0.0002351932,0.02440535,0.0006700259,0.001016899,0.0103645],"study_design_scores_gemma":[0.03889696,0.001609484,0.9434137,0.00009404068,0.001677297,0.00002321736,0.0003483529,0.00005301862,0.01265401,0.0002739797,0.0008243,0.0001316923],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923304,0.0008377697,0.00001009127,0.002968112,0.000147938,0.0003673906,0.0001095783,0.000008995843,0.003219692],"genre_scores_gemma":[0.9991943,0.0002167566,0.0000544705,0.00007590657,0.00005075585,0.0000498585,0.00006069562,0.000005269218,0.0002920183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06381617,"threshold_uncertainty_score":0.2847978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04119417160271137,"score_gpt":0.3350772450676097,"score_spread":0.2938830734648983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}