{"id":"W3189599545","doi":"10.3934/math.2021631","title":"Impact of estrogen population pharmacokinetics on a QSP model of mammary stem cell differentiation into myoepithelial cells","year":2021,"lang":"en","type":"article","venue":"AIMS Mathematics","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Myoepithelial cell; Estrogen; Population; Estrogen receptor; Stem cell; Biology; Cell; Cancer research; Pharmacokinetics; Cell biology; Cancer; Endocrinology; Pharmacology; Breast cancer; Medicine; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009486874,0.000150893,0.0004180025,0.00008638427,0.00001796225,0.000007934488,0.00006896324,0.0000673112,0.00006034671],"category_scores_gemma":[0.000008196116,0.0001251702,0.0002548627,0.0001549885,0.00001747276,0.00004258744,0.0000426188,0.00009212636,0.000005065935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000844801,"about_ca_system_score_gemma":0.0001249452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004150108,"about_ca_topic_score_gemma":0.000002199036,"domain_scores_codex":[0.9988841,0.00002501791,0.000466162,0.0001559409,0.0003331674,0.0001356488],"domain_scores_gemma":[0.9990171,0.00005250628,0.0003120371,0.0003649542,0.0001714207,0.00008198218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001238491,0.001641574,0.001325234,0.002127716,0.000241688,0.000007337803,0.001932911,0.007280819,0.9697796,0.000778579,0.0003099668,0.01445073],"study_design_scores_gemma":[0.001598624,0.0003653963,0.0008917583,0.0002143239,0.0005434628,0.000006381048,0.00011157,0.1051286,0.8891327,0.001846757,0.0000195474,0.0001409132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753318,0.0002001413,0.02353824,0.00003025863,0.0001055924,0.0002411756,0.00006577891,0.0000164987,0.0004704995],"genre_scores_gemma":[0.977746,0.000281188,0.02140019,0.00002551778,0.00005314575,0.000005669051,0.00006026692,0.0000275721,0.0004004299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09784776,"threshold_uncertainty_score":0.5104292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02556767168498906,"score_gpt":0.2981726717399137,"score_spread":0.2726050000549247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}