{"id":"W3189636333","doi":"10.21203/rs.3.rs-779341/v1","title":"Impact of Neoadjuvant Chemotherapy on Somatic Mutation Status in High-grade Serous Ovarian Carcinoma","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute; University of Toronto; University Health Network","funders":"University of Toronto; Princess Margaret Cancer Foundation; University Health Network","keywords":"Somatic cell; Chemotherapy; Cisplatin; Oncology; Ovarian carcinoma; Carboplatin; Mutation; Exome sequencing; Germline mutation; Internal medicine; Medicine; Serous carcinoma; Ovarian cancer; Gene; Cancer research; Biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002169344,0.00008513338,0.0002112713,0.0001838343,0.0001231417,0.000298878,0.00008056898,0.0001312302,0.0007966802],"category_scores_gemma":[0.0009917803,0.00005076027,0.0001613201,0.0002386921,0.0001526984,0.0001270524,0.0001303075,0.0001491681,0.00007518688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002783068,"about_ca_system_score_gemma":0.0001692579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006089073,"about_ca_topic_score_gemma":0.001409066,"domain_scores_codex":[0.9998599,0.00004081007,0.00002157059,0.00002599616,0.00003722709,0.00001445921],"domain_scores_gemma":[0.9995267,0.000196724,0.0001430804,0.00002707547,0.00004144643,0.00006488109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002291257,0.00006857229,0.9397713,0.00009896197,0.0001196738,0.0008151285,0.00006710217,0.0004814061,0.03270496,0.0000410903,0.0001677216,0.02337285],"study_design_scores_gemma":[0.00001400781,0.0005255875,0.9911857,0.00001381282,0.00008646659,0.002035907,0.00007880588,0.0006240277,0.004715438,0.00004598429,0.0006702614,0.00000396574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986739,0.0007676634,0.00005834836,0.0000369509,0.000004651273,0.000003285326,0.000100919,0.000003020413,0.0003512208],"genre_scores_gemma":[0.9995797,0.0001544422,0.00008737241,0.00001789316,0.000002512827,0.000002090465,0.000102047,0.000001226067,0.00005265585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007966802,"threshold_uncertainty_score":0.002665162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05733183093884633,"score_gpt":0.4132476366290551,"score_spread":0.3559158056902088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}