{"id":"W3189652011","doi":"10.1126/sciadv.abf4416","title":"Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute","funders":"Nanfang Hospital; Guangzhou Municipal Science and Technology Project; China Postdoctoral Science Foundation; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Stem cell; Trophoblast; Induced pluripotent stem cell; Placentation; Cell biology; Biology; Embryonic stem cell; Genetics; Pregnancy; Placenta; Fetus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000359773,0.000163236,0.0002004665,0.00008778954,0.0002328456,0.0000550169,0.0005690504,0.00006904935,0.00002797691],"category_scores_gemma":[0.00001457615,0.0001504366,0.00008581577,0.0005195484,0.0005661632,0.00001531336,0.0003426856,0.0000911688,0.00002441544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005620723,"about_ca_system_score_gemma":0.0003328112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001746346,"about_ca_topic_score_gemma":0.00002341181,"domain_scores_codex":[0.9976283,0.00008365884,0.0003368529,0.0007427462,0.0007686552,0.0004397868],"domain_scores_gemma":[0.9987077,0.00002619354,0.000180589,0.0005767381,0.0003617527,0.0001470983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002243433,0.0001050603,0.000204123,0.00002994909,0.000009579681,0.000007168575,0.00006989946,0.005304661,0.989043,0.00001372985,0.00003186029,0.005158563],"study_design_scores_gemma":[0.0003388356,0.0001710978,0.0004170782,0.00003844617,0.000007137823,0.000001975633,0.0004462577,0.0003933984,0.9952163,0.0000200937,0.002783959,0.0001654624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954691,0.001995118,0.001501227,0.0000458546,0.0003549575,0.0002143451,0.00004245798,0.00001173681,0.0003652064],"genre_scores_gemma":[0.9974031,0.0001275464,0.001203988,0.0000376051,0.00007264295,0.00001249914,0.00001699535,0.00001380308,0.001111789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006173286,"threshold_uncertainty_score":0.6134625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383923694883411,"score_gpt":0.2709682790072931,"score_spread":0.257129042058459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}