{"id":"W3189652011","doi":"10.1126/sciadv.abf4416","title":"Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute","funders":"Nanfang Hospital; Guangzhou Municipal Science and Technology Project; China Postdoctoral Science Foundation; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Stem cell; Trophoblast; Induced pluripotent stem cell; Placentation; Cell biology; Biology; Embryonic stem cell; Genetics; Pregnancy; Placenta; Fetus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002561036,0.000233368,0.0001672139,0.0002469311,0.0001992074,0.0002504658,0.0001592887,0.0001911471,0.002117008],"category_scores_gemma":[0.0002528614,0.0001866729,0.0001784296,0.0001911291,0.0001553533,0.0001446023,0.0003642883,0.0004992863,0.001004799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001296261,"about_ca_system_score_gemma":0.000382231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003345285,"about_ca_topic_score_gemma":0.0006396607,"domain_scores_codex":[0.9998676,0.00002682282,0.00002295159,0.00002306183,0.00004691382,0.0000126121],"domain_scores_gemma":[0.9999187,0.00001887291,0.00001425852,0.00001769235,0.00001010861,0.00002028105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001309487,0.00002391915,0.0008309107,0.00008999478,0.00001016233,0.0003455195,0.00009829988,0.0003350202,0.9878293,0.001841114,0.0004629484,0.008001936],"study_design_scores_gemma":[0.00004180121,0.0002692214,0.004136708,0.00003279941,0.00003885829,0.00163186,0.00006076039,0.001838565,0.9558607,0.0007471461,0.03532843,0.00001316356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8361437,0.004418728,0.1259628,0.0004784224,0.0002884633,0.001512319,0.009859529,0.001217773,0.02011819],"genre_scores_gemma":[0.9114711,0.003469747,0.0678542,0.0001613857,0.00004202648,0.0005650206,0.006540352,0.0001337187,0.00976235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002117008,"threshold_uncertainty_score":0.007082105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383923694883411,"score_gpt":0.2709682790072931,"score_spread":0.257129042058459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}