{"id":"W3189729982","doi":"10.3389/fphar.2021.728296","title":"Modulatory Effect of 4-(methylthio)butyl Isothiocyanate Isolated From Eruca Sativa Thell. on DMBA Induced Overexpression of Hypoxia and Glycolytic Pathway in Sprague-Dawley Female Rats","year":2021,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Science and Engineering Research Board; Indian Council of Medical Research; Department of Science and Technology, Ministry of Science and Technology, India","keywords":"DMBA; PI3K/AKT/mTOR pathway; Chemistry; Isothiocyanate; Eruca; Protein kinase B; Biochemistry; Hypoxia (environmental); Pharmacology; Internal medicine; Endocrinology; Signal transduction; Biology; Medicine; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006798859,0.0004181801,0.0002681073,0.0003661629,0.0001561239,0.0001404746,0.0001543578,0.000234869,0.001184806],"category_scores_gemma":[0.00007278754,0.0001131072,0.0002451029,0.0001412697,0.00015798,0.0001611467,0.0001081148,0.0005355439,0.0002046177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002033936,"about_ca_system_score_gemma":0.000219487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001355873,"about_ca_topic_score_gemma":0.002356729,"domain_scores_codex":[0.9999574,0.000005641512,0.000003013643,0.000009316392,0.000009965705,0.00001465207],"domain_scores_gemma":[0.99994,0.000005338413,0.00002034467,0.000005627379,0.00001027618,0.00001833115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005209348,0.00008980292,0.000127558,0.00005625648,0.000007210134,0.00003844941,0.000008961354,0.00002863624,0.9972335,0.00003206012,0.00003705283,0.001819659],"study_design_scores_gemma":[0.00008243181,0.003150434,0.008929135,0.00001672221,0.00007409251,0.0001669482,0.00003954368,0.0002971401,0.9830204,0.0000608769,0.004151272,0.00001111304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993677,0.002816004,0.001307169,0.0002714706,0.00006063638,0.00002835454,0.000391055,0.0001219778,0.001326354],"genre_scores_gemma":[0.9898677,0.002492154,0.001897833,0.0001955746,0.00002289238,0.00004197779,0.0005775424,0.00003109005,0.00487321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001355873,"threshold_uncertainty_score":0.00396353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008039687811421841,"score_gpt":0.2570593566775391,"score_spread":0.2490196688661173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}