{"id":"W3189762741","doi":"10.1002/smll.202103025","title":"Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery","year":2021,"lang":"en","type":"article","venue":"Small","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Centre for Drug Research and Development; Acuitas Therapeutics (Canada); BC Innovation Council; University of British Columbia","funders":"H2020 Marie Skłodowska-Curie Actions; BC Cancer Agency; Stichting voor de Technische Wetenschappen; University of British Columbia; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canadian Institutes of Health Research; European Commission","keywords":"Prodrug; Small interfering RNA; Chemistry; Pharmacology; Gene silencing; Biodistribution; Nucleic acid; Small molecule; Nanotechnology; RNA; In vitro; Biochemistry; Materials science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007192898,0.0001140343,0.0001185019,0.00003633616,0.00007219994,0.00002428727,0.000119983,0.0001508375,0.000008999946],"category_scores_gemma":[0.00007686269,0.0001125094,0.00005719036,0.00007758361,0.00006070235,0.000004488988,0.0001520936,0.00005745654,0.00001043289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006863784,"about_ca_system_score_gemma":0.00006649666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005985152,"about_ca_topic_score_gemma":0.00008271483,"domain_scores_codex":[0.9992167,0.000009166277,0.0001393701,0.000353921,0.00004310946,0.0002377783],"domain_scores_gemma":[0.9994636,0.000007436931,0.00003499969,0.0002962255,0.0001430892,0.0000546259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005514024,0.00004356011,0.001037205,0.00002395492,0.00004156843,0.000006870085,0.00002917343,0.00001559605,0.9854779,0.0002083971,0.0004158716,0.01264472],"study_design_scores_gemma":[0.0004652668,0.0003257372,0.0005071466,0.00001396576,0.00001911489,0.00004618997,0.0001376008,0.0002267704,0.9713562,0.0007989238,0.02594487,0.0001582622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962279,0.002324257,0.0003452923,0.0006012422,0.0001343624,0.0001585812,0.00001981521,0.00001996679,0.0001686402],"genre_scores_gemma":[0.9964272,0.0003877627,0.001299709,0.000357293,0.0001903285,0.00005063828,0.00005937919,0.00001651365,0.001211112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.025529,"threshold_uncertainty_score":0.4587999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01610585150482724,"score_gpt":0.2258683030359557,"score_spread":0.2097624515311284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}