{"id":"W3189762741","doi":"10.1002/smll.202103025","title":"Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery","year":2021,"lang":"en","type":"article","venue":"Small","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Centre for Drug Research and Development; Acuitas Therapeutics (Canada); BC Innovation Council; University of British Columbia","funders":"H2020 Marie Skłodowska-Curie Actions; BC Cancer Agency; Stichting voor de Technische Wetenschappen; University of British Columbia; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canadian Institutes of Health Research; European Commission","keywords":"Prodrug; Small interfering RNA; Chemistry; Pharmacology; Gene silencing; Biodistribution; Nucleic acid; Small molecule; Nanotechnology; RNA; In vitro; Biochemistry; Materials science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001944846,0.0006149412,0.0002483371,0.0003325967,0.0001806439,0.0002924652,0.0003367945,0.000448487,0.001177213],"category_scores_gemma":[0.0001295204,0.000240639,0.0003273917,0.0001771264,0.0002319804,0.0004313138,0.0003909602,0.0006214523,0.0009579906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005251041,"about_ca_system_score_gemma":0.0003902722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003267147,"about_ca_topic_score_gemma":0.0004109831,"domain_scores_codex":[0.9998897,0.00001250382,0.000007491237,0.00003325696,0.00004022895,0.00001667641],"domain_scores_gemma":[0.9999559,0.000006993846,0.00001583512,0.000005793835,0.00000783187,0.000007640513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002111995,0.0000123367,0.00002553132,0.00005432918,0.000005353003,0.00005706946,0.00001556649,0.0002748173,0.9945663,0.0009492832,0.00008286028,0.003935329],"study_design_scores_gemma":[0.00001120409,0.000169684,0.0001565116,0.00000525148,0.00001568224,0.0002094941,0.000005310992,0.002005917,0.9891106,0.0001716381,0.008129105,0.000009495546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4814085,0.006945929,0.4960521,0.0006680054,0.0002779702,0.0006538249,0.0005407408,0.002284281,0.01116868],"genre_scores_gemma":[0.8297898,0.003847461,0.1517318,0.0002178921,0.00003677628,0.0005441094,0.0005220509,0.0001272547,0.01318283],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001177213,"threshold_uncertainty_score":0.003938198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01610585150482724,"score_gpt":0.2258683030359557,"score_spread":0.2097624515311284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}