{"id":"W3189898401","doi":"10.1128/mbio.01477-21","title":"Targeting Polyphosphate Kinases in the Fight against Pseudomonas aeruginosa","year":2021,"lang":"en","type":"letter","venue":"mBio","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Polyphosphate; Pseudomonas aeruginosa; Kinase; Biofilm; Virulence; Enzyme; Bacteria; Microbiology; Biology; Biochemistry; Computational biology; Cell biology; Gene; Genetics; Phosphate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000391114,0.0005694188,0.0008317585,0.0002269495,0.0001991802,0.000147986,0.0003968563,0.0007414548,0.000668902],"category_scores_gemma":[0.0002481919,0.0004249535,0.0004252416,0.0005559731,0.0001231944,0.000104608,0.0001085061,0.001639783,0.000155127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001298912,"about_ca_system_score_gemma":0.0002929615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005186343,"about_ca_topic_score_gemma":0.00004009596,"domain_scores_codex":[0.9967407,0.0002100342,0.0007201871,0.000747332,0.0007695686,0.0008121885],"domain_scores_gemma":[0.9982572,0.0004267311,0.0002763229,0.0008189501,0.0001295781,0.00009118708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002475559,0.00009173446,0.006067073,0.0002686598,0.0000859863,0.004649403,0.0008206086,0.000005740157,0.0002740286,0.00004734187,0.9849018,0.002762849],"study_design_scores_gemma":[0.001021917,0.00006874114,0.005946304,0.0008438557,0.0001643852,0.0001308251,0.0003015127,0.00009904287,0.001572484,0.0001017524,0.9892164,0.0005328033],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03273173,0.04027596,0.00002208055,0.9150838,0.001888065,0.00147731,0.0001222892,0.0002221027,0.008176654],"genre_scores_gemma":[0.04171535,0.001026379,0.0002675779,0.9356197,0.007276971,0.0001582152,0.004239908,0.000131878,0.009564054],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03924958,"threshold_uncertainty_score":0.9998202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02347470512287294,"score_gpt":0.2553075523879969,"score_spread":0.2318328472651239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}