{"id":"W3189914523","doi":"10.1038/s41598-021-95635-x","title":"Dexmedetomidine does not compromise neuronal viability, synaptic connectivity, learning and memory in a rodent model","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Ontario Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Turun Yliopisto","keywords":"Dexmedetomidine; Neuroscience; Compromise; Rodent model; Functional connectivity; Computer science; Psychology; Medicine; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001899954,0.0001922369,0.0003187653,0.0002143864,0.000474446,0.0004573841,0.0001760966,0.00007116752,0.00009296235],"category_scores_gemma":[0.003401291,0.0001613032,0.00008257981,0.0006024402,0.0006795522,0.0002878711,0.0004762209,0.0004847144,0.00001352204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006175226,"about_ca_system_score_gemma":0.0003008708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002237344,"about_ca_topic_score_gemma":0.00009406325,"domain_scores_codex":[0.9958447,0.0005426591,0.0004756174,0.001663688,0.0009384656,0.0005348926],"domain_scores_gemma":[0.9984192,0.0005133685,0.0001481058,0.0005980204,0.00009715751,0.0002241269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003486237,0.0002274626,0.02074968,0.00005942057,0.000001600436,0.003948686,0.0002124049,0.002621897,0.9716371,0.00009341507,0.00003279635,0.000380678],"study_design_scores_gemma":[0.0001659393,0.00004068825,0.002058069,0.00002686427,0.000005769555,0.001391894,0.00005713273,0.1132504,0.8791705,0.003390475,0.0002534445,0.000188816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972596,0.00002319583,0.00005761156,0.0008248108,0.0007604313,0.0004973842,0.000001544963,0.00007916681,0.0004963194],"genre_scores_gemma":[0.9955815,0.00001399694,0.00007283264,0.0001554225,0.00002546156,0.0000484704,0.000002584358,0.00002172024,0.004077982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1106285,"threshold_uncertainty_score":0.6577753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04074177114510248,"score_gpt":0.2983957211193977,"score_spread":0.2576539499742952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}