{"id":"W3189938671","doi":"10.1101/2021.08.10.455857","title":"Stable Flow-induced Expression of KLK10 Inhibits Endothelial Inflammation and Atherosclerosis","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"","keywords":"Inflammation; Endothelial dysfunction; Gene knockdown; Cell biology; Endothelial stem cell; Biology; Cancer research; Molecular biology; Chemistry; Immunology; In vitro; Biochemistry; Apoptosis; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001917817,0.000520126,0.00036648,0.0002531298,0.0001337881,0.0003398222,0.0002246506,0.0003023282,0.002979296],"category_scores_gemma":[0.0001109148,0.0001385512,0.0003481395,0.0001755543,0.0003033006,0.0001938099,0.0001828887,0.0009520466,0.0007280851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003992721,"about_ca_system_score_gemma":0.0003584402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006487544,"about_ca_topic_score_gemma":0.00092446,"domain_scores_codex":[0.99975,0.00003334192,0.00002726218,0.00005028477,0.00005132224,0.00008773357],"domain_scores_gemma":[0.9998813,0.00001551898,0.00003375891,0.00001232763,0.00001512594,0.00004205116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003851475,0.0001210759,0.0001009553,0.0001058342,0.000008548207,0.00002196925,0.00001098262,0.0000640021,0.997465,0.00006899452,0.0002094633,0.001438052],"study_design_scores_gemma":[0.0001183575,0.001228056,0.004051635,0.00001467715,0.00003382424,0.0001840418,0.00003266735,0.001200723,0.9888208,0.00006826413,0.004235949,0.00001106066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823099,0.004179401,0.00676407,0.0003841972,0.0002632801,0.0001253575,0.002009796,0.0006411856,0.003322899],"genre_scores_gemma":[0.9860913,0.001865803,0.003689472,0.000210164,0.00004915073,0.0001706761,0.002037324,0.00005853886,0.005827587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002979296,"threshold_uncertainty_score":0.009966791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01970509757002255,"score_gpt":0.2264650618100371,"score_spread":0.2067599642400145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}