{"id":"W3189990854","doi":"10.3390/molecules26154640","title":"IEDDA: An Attractive Bioorthogonal Reaction for Biomedical Applications","year":2021,"lang":"en","type":"review","venue":"Molecules","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF","funders":"KWF Kankerbestrijding","keywords":"Bioorthogonal chemistry; Chemistry; Nanotechnology; Combinatorial chemistry; Materials science; Click chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004562983,0.0007575203,0.0004708027,0.0006130814,0.0001558092,0.0006909157,0.0004124858,0.0009130025,0.0009551707],"category_scores_gemma":[0.0002470691,0.0003737888,0.0003902097,0.0005015614,0.0003701827,0.0007493565,0.0006411038,0.001303271,0.0008298387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003072383,"about_ca_system_score_gemma":0.0001811763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001586672,"about_ca_topic_score_gemma":0.0001396069,"domain_scores_codex":[0.9997055,0.00003892498,0.00002167187,0.00008821308,0.000096261,0.00004940261],"domain_scores_gemma":[0.9999216,0.00001775964,0.00002384635,0.000009112409,0.00001624404,0.00001150125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005458996,0.00005632407,0.00009299367,0.0002715701,0.00001431211,0.0001225017,0.00003989886,0.0002426809,0.9628074,0.003792807,0.0005557745,0.03194906],"study_design_scores_gemma":[0.00001689684,0.0002169745,0.0002355077,0.00001525324,0.0000189645,0.0005508734,0.0000103039,0.001307912,0.9620873,0.0005770288,0.0349408,0.00002225131],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.3451859,0.1312287,0.4817462,0.001956555,0.001218509,0.0005873606,0.0007144181,0.001957333,0.03540494],"genre_scores_gemma":[0.7747998,0.04915843,0.1510929,0.001254576,0.0002180648,0.0004397911,0.0008607776,0.0001782303,0.02199748],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0009551707,"threshold_uncertainty_score":0.003195345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07989948542073483,"score_gpt":0.3925937709119492,"score_spread":0.3126942854912144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}