{"id":"W3190049739","doi":"10.2196/30131","title":"Modulation of Bone and Joint Biomarkers, Gut Microbiota, and Inflammation Status by Synbiotic Supplementation and Weight-Bearing Exercise: Human Study Protocol for a Randomized Controlled Trial","year":2021,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Massey University","keywords":"Medicine; Randomized controlled trial; Prebiotic; Gut flora; Physical therapy; Probiotic; Internal medicine; Osteoarthritis; Immunology; Alternative medicine; Biology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03801937,0.008543725,0.019483,0.002616109,0.005814502,0.005484005,0.005118064,0.01307386,0.08708882],"category_scores_gemma":[0.03217693,0.004684403,0.006419231,0.00447131,0.006509047,0.005153625,0.003342143,0.01105766,0.01954911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005711962,"about_ca_system_score_gemma":0.02342755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003292,"about_ca_topic_score_gemma":0.00631633,"domain_scores_codex":[0.9746279,0.01346271,0.002837671,0.002858026,0.002917539,0.003296109],"domain_scores_gemma":[0.9833121,0.00309992,0.003298618,0.002636919,0.004390063,0.003262427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9250547,0.0214162,0.000576204,0.0146179,0.001709558,0.0002378853,0.0002964559,0.001056205,0.002459371,0.002752034,0.01104947,0.01877395],"study_design_scores_gemma":[0.9325338,0.0352215,0.001448489,0.00274923,0.0008991085,0.00004790023,0.00008152542,0.001102322,0.0005769199,0.001909425,0.02331226,0.0001174222],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.001122418,0.0003066613,0.0009659727,0.0001415837,0.0002823854,0.9961544,0.0005575083,0.00007004723,0.0003991188],"genre_scores_gemma":[0.001192847,0.0001461814,0.001284787,0.000143132,0.00006176665,0.9967079,0.00009375658,0.000005035166,0.0003645598],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.08708882,"threshold_uncertainty_score":0.2913411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07075749987758326,"score_gpt":0.4789368783328239,"score_spread":0.4081793784552407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}