{"id":"W3190087660","doi":"10.1093/ijnp/pyab056","title":"Antioxidative Defense Genes and Brain Structure in Youth Bipolar Disorder","year":2021,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; Sunnybrook Health Science Centre; Centre for Addiction and Mental Health; University of Toronto","funders":"National Institute of Mental Health; University of Toronto; Canadian Institutes of Health Research; Ontario Mental Health Foundation; Fondation Brain Canada; Heart and Stroke Foundation of Canada","keywords":"SOD2; Single-nucleotide polymorphism; Anterior cingulate cortex; Frontal lobe; Bipolar disorder; Psychology; Internal medicine; Neuroscience; Biology; Medicine; Genetics; Genotype; Superoxide dismutase; Oxidative stress; Gene; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001121084,0.00009841404,0.0001774237,0.0001326311,0.0000284161,0.00001731691,0.0001380701,0.00003822389,0.0002010444],"category_scores_gemma":[0.00006848213,0.00006466598,0.00006889288,0.0001204597,0.00007591307,0.00006085242,0.00005446157,0.0003118731,0.000002560774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002894849,"about_ca_system_score_gemma":0.00009544906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000142083,"about_ca_topic_score_gemma":0.00006139046,"domain_scores_codex":[0.9991292,0.0001560138,0.0002662562,0.0001222816,0.0002189037,0.0001073908],"domain_scores_gemma":[0.9993416,0.0001347652,0.0001379217,0.00007458146,0.0002525401,0.00005861406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002429001,0.0008870218,0.3361649,0.00001563621,0.001231939,0.002198367,0.002939206,0.0000933924,0.5735739,0.0003293425,0.0007790111,0.07935821],"study_design_scores_gemma":[0.0136191,0.0006105484,0.9120259,0.00006247121,0.0003823467,0.01072234,0.000966752,0.0001172462,0.01324459,0.001196999,0.04688725,0.0001644917],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633626,0.01651644,0.00003622755,0.01900342,0.0008549732,0.00007933607,0.00003294886,0.000003903783,0.0001101696],"genre_scores_gemma":[0.9925725,0.003894056,0.000119614,0.003090623,0.0002148749,8.136733e-7,0.00000852745,0.00001179547,0.00008712454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5758609,"threshold_uncertainty_score":0.2637002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611187520375922,"score_gpt":0.3146434043705779,"score_spread":0.2985315291668187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}