{"id":"W3190088157","doi":"10.1371/journal.ppat.1009719","title":"Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; BC Children's Hospital; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Canadian Institutes of Health Research; CH.I.L.D. Foundation; Crohn's and Colitis Canada; University of British Columbia; Canada Research Chairs; Michael Smith Health Research BC; BC Children's Hospital","keywords":"Salmonella enterica; Virulence; Salmonella; Colonisation resistance; Salmonella infection; Microbiology; Biology; Pathogen; Microbiome; Gastrointestinal tract; Intestinal epithelium; Host (biology); Gut flora; Immunology; Immune system; Colonization; Bacteria; Epithelium; Gene; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071068,0.0001313857,0.0001235989,0.00006165877,0.0002276895,0.00005963406,0.00004511784,0.0001183541,0.00001820274],"category_scores_gemma":[0.0001935805,0.0001488285,0.00003264597,0.0001117631,0.00005414776,0.00001052216,0.00005946599,0.00005559945,0.000002291697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002994342,"about_ca_system_score_gemma":0.0002093428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001087288,"about_ca_topic_score_gemma":0.0002320752,"domain_scores_codex":[0.9989716,0.0002223552,0.0001963509,0.0003555518,0.00005529608,0.0001987951],"domain_scores_gemma":[0.9994649,0.00001551099,0.00010465,0.0001937383,0.0001368964,0.00008434719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003124614,0.000104212,0.03015603,0.0001277013,0.00001655667,0.00001819448,0.00006001607,0.000002819834,0.9691302,0.000001510913,0.00002592538,0.00004433743],"study_design_scores_gemma":[0.0004508806,0.0000867948,0.2134132,0.00007256527,0.00001973621,0.00002504356,0.0000289591,0.000006407442,0.7849952,8.040166e-7,0.0007647349,0.0001356616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999163,0.0003190921,0.00003828835,0.00006715315,0.00009666535,0.0001303095,0.0001365768,0.00002857796,0.00002032801],"genre_scores_gemma":[0.9979309,0.0001874112,0.0008332512,0.00008256039,0.00023743,0.00001372588,0.0005315415,0.00002389904,0.0001593095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.184135,"threshold_uncertainty_score":0.6069049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062581733729033,"score_gpt":0.2340164533107759,"score_spread":0.2233906359734856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}