{"id":"W3190088157","doi":"10.1371/journal.ppat.1009719","title":"Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; BC Children's Hospital; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Canadian Institutes of Health Research; CH.I.L.D. Foundation; Crohn's and Colitis Canada; University of British Columbia; Canada Research Chairs; Michael Smith Health Research BC; BC Children's Hospital","keywords":"Salmonella enterica; Virulence; Salmonella; Colonisation resistance; Salmonella infection; Microbiology; Biology; Pathogen; Microbiome; Gastrointestinal tract; Intestinal epithelium; Host (biology); Gut flora; Immunology; Immune system; Colonization; Bacteria; Epithelium; Gene; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001210783,0.000294839,0.0003626893,0.0002054344,0.0001416687,0.0003083604,0.0001289234,0.0002725275,0.001251486],"category_scores_gemma":[0.0001919531,0.0001429906,0.000210721,0.00009818494,0.0003015892,0.0001875843,0.0002463127,0.0006713243,0.0001496946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020185,"about_ca_system_score_gemma":0.0002122489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000333059,"about_ca_topic_score_gemma":0.0009762131,"domain_scores_codex":[0.9998934,0.00002054966,0.000008503015,0.00002191916,0.00001635718,0.0000392822],"domain_scores_gemma":[0.999781,0.00002145454,0.00007223822,0.00001938067,0.00001507196,0.00009092339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003705303,0.0002269642,0.001374066,0.00009311458,0.00001802918,0.00007054774,0.00003201623,0.00008325511,0.9877678,0.00005586611,0.0001500949,0.006422928],"study_design_scores_gemma":[0.0004193953,0.02139131,0.2900258,0.0001239852,0.0001847069,0.0007457082,0.0005342817,0.001621901,0.6779234,0.000543157,0.006401748,0.00008450098],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997494,0.001063703,0.0004598029,0.0001217206,0.00003743456,0.00001450158,0.0002047939,0.00007564449,0.0005284467],"genre_scores_gemma":[0.9964981,0.0008560793,0.0009749564,0.0001517782,0.00001794115,0.00002958892,0.0002753682,0.00002311669,0.001173084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251486,"threshold_uncertainty_score":0.00418663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062581733729033,"score_gpt":0.2340164533107759,"score_spread":0.2233906359734856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}