{"id":"W3190141894","doi":"10.1016/s1470-2045(21)00376-4","title":"Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): an open-label, phase 2 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":277,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Centre for Mathematical Cognition, Loughborough University; Pfizer UK; Pfizer","keywords":"Medicine; Prostate cancer; Enzalutamide; Oncology; Internal medicine; PARP inhibitor; Clinical endpoint; Docetaxel; Cancer; Clinical trial; Poly ADP ribose polymerase; Androgen receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001087829,0.001732554,0.001976119,0.0003620288,0.0002938658,0.001053831,0.0006802331,0.001236747,0.006373036],"category_scores_gemma":[0.000861356,0.0004301717,0.001693175,0.0003499607,0.0007474099,0.0009271023,0.0002985818,0.003076918,0.0010585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008737564,"about_ca_system_score_gemma":0.0009656717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00117166,"about_ca_topic_score_gemma":0.004608686,"domain_scores_codex":[0.9997402,0.00009697892,0.000009163108,0.00005320436,0.0000259731,0.0000744196],"domain_scores_gemma":[0.9996424,0.00008139785,0.00006714129,0.00002037259,0.00002152302,0.0001671659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7880313,0.01673841,0.002351904,0.00266997,0.003917686,0.0003341802,0.0002255095,0.003349659,0.01872494,0.0009811637,0.01283339,0.1498418],"study_design_scores_gemma":[0.8514835,0.1351338,0.003720338,0.0001170277,0.001052178,0.0003656658,0.00008184622,0.001607745,0.0015508,0.0006293026,0.004204581,0.00005313345],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747617,0.01238145,0.000890435,0.002219369,0.000622206,0.001670914,0.00251476,0.000332283,0.004606872],"genre_scores_gemma":[0.978501,0.007569927,0.001368095,0.002308051,0.0003460192,0.001219116,0.002913902,0.00005614991,0.00571776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006373036,"threshold_uncertainty_score":0.02131999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1727428949262219,"score_gpt":0.4787019484634764,"score_spread":0.3059590535372544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}