{"id":"W3190426039","doi":"10.1016/j.stem.2021.07.003","title":"TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate","year":2021,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Eidgenössische Technische Hochschule Zürich; University of Toronto; European Molecular Biology Organization; Canadian Cancer Society; Canada First Research Excellence Fund; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; International Development Research Centre; Canada Research Chairs; Government of Ontario; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"Biology; TFEB; Haematopoiesis; Cell biology; Stem cell; Hematopoietic stem cell; Cell; Immunology; Lysosome; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001406031,0.0001202396,0.0001327386,0.0002090108,0.0001729193,0.0004303917,0.00009179742,0.0001744172,0.001448368],"category_scores_gemma":[0.000182772,0.00008141507,0.0001025698,0.0001352693,0.0001624482,0.000192328,0.0001321537,0.0002238646,0.0003536366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003202781,"about_ca_system_score_gemma":0.0001676841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007111047,"about_ca_topic_score_gemma":0.0009149937,"domain_scores_codex":[0.9999298,0.0000125884,0.00000511785,0.00001582656,0.00001192955,0.00002470309],"domain_scores_gemma":[0.9998955,0.00004194966,0.00001518721,0.00001310577,0.00001398649,0.0000203638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001574402,0.000007351382,0.0003247329,0.000009708879,0.000001669987,0.00004046509,0.00001345113,0.00003695074,0.9979054,0.0002210962,0.00002559513,0.001256263],"study_design_scores_gemma":[0.00000887458,0.00003637554,0.004305015,0.000001975467,0.000004072569,0.0001668453,0.00002768673,0.0007484902,0.993628,0.00008840552,0.0009822499,0.000002032519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934408,0.001586835,0.002950315,0.00007313333,0.00001397686,0.000009913286,0.0003198701,0.00006324812,0.001541963],"genre_scores_gemma":[0.997911,0.0002391671,0.0005227348,0.00001112084,0.000003277461,0.000005058157,0.0002001182,0.000009791281,0.00109763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001448368,"threshold_uncertainty_score":0.004845262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178478255796184,"score_gpt":0.2243485805764821,"score_spread":0.2125637980185202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}