{"id":"W3190426039","doi":"10.1016/j.stem.2021.07.003","title":"TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate","year":2021,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Eidgenössische Technische Hochschule Zürich; University of Toronto; European Molecular Biology Organization; Canadian Cancer Society; Canada First Research Excellence Fund; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; International Development Research Centre; Canada Research Chairs; Government of Ontario; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"Biology; TFEB; Haematopoiesis; Cell biology; Stem cell; Hematopoietic stem cell; Cell; Immunology; Lysosome; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002775872,0.0004213089,0.0005335411,0.00005738033,0.000224655,0.0001057453,0.000330978,0.0003458211,0.0001674001],"category_scores_gemma":[0.000005645841,0.0004313792,0.0003676498,0.0001585423,0.00009098703,0.000008634974,0.0002425,0.0003005,0.0002477356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002630823,"about_ca_system_score_gemma":0.0001287597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002204754,"about_ca_topic_score_gemma":0.000008884615,"domain_scores_codex":[0.9974513,0.0003027789,0.0004300523,0.000854986,0.0003126716,0.0006481772],"domain_scores_gemma":[0.9983926,0.00007165997,0.0002491172,0.0008284652,0.0001633654,0.0002948367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005741624,0.000395589,0.0003685242,0.0001704528,0.00003350791,0.00008653705,0.0001016181,0.00004765148,0.9969203,0.00002058622,0.001133325,0.0006644948],"study_design_scores_gemma":[0.002534841,0.0001415377,0.0003222646,0.00001660171,0.00009345153,0.00001986191,0.0002439878,0.00006356308,0.9661201,0.00001234573,0.02995505,0.0004763631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798127,0.007136914,0.0004516691,0.00006194857,0.0004762652,0.000282252,0.0000693693,0.00006784801,0.01164099],"genre_scores_gemma":[0.9840906,0.0002486454,0.00006096664,0.0002356622,0.0003637692,0.00003075659,0.0001699024,0.00008544103,0.0147143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03080016,"threshold_uncertainty_score":0.9998138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178478255796184,"score_gpt":0.2243485805764821,"score_spread":0.2125637980185202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}