{"id":"W3190517567","doi":"10.15252/emmm.202113929","title":"Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis","year":2021,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Medical Research Council; Instituto de Salud Carlos III; Università di Pisa; Generalitat de Catalunya; ZonMw; Nottingham Trent University; LAM Foundation; Lam Research; Tuberous Sclerosis Association","keywords":"Lymphangioleiomyomatosis; Histamine; Pharmacology; Biology; Aprepitant; Medicine; Cancer research; Bioinformatics; Internal medicine; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005170078,0.0002473167,0.0005971173,0.0002588379,0.0001493463,0.00004554516,0.00008688104,0.0001045338,0.0001888012],"category_scores_gemma":[0.0004101663,0.0002062806,0.0001111188,0.0003433712,0.0003880815,0.00006553943,0.0001249842,0.000106224,0.000002591777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004079204,"about_ca_system_score_gemma":0.00009183175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006663855,"about_ca_topic_score_gemma":0.000004664854,"domain_scores_codex":[0.9980177,0.000119746,0.0003584962,0.0005386543,0.0005421484,0.0004232991],"domain_scores_gemma":[0.9987702,0.0001478062,0.00007467435,0.0003649241,0.0003254577,0.0003169706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001295936,0.00006008144,0.0006350937,0.0002468195,0.0005905602,0.0003018253,0.0004119684,0.000001000642,0.9853114,0.0007786102,0.0008348987,0.01069819],"study_design_scores_gemma":[0.03687491,0.00122209,0.2483943,0.002038982,0.003595177,0.003711879,0.004922085,0.003053221,0.660863,0.00436818,0.02972491,0.001231229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9198127,0.05290189,0.01409465,0.01213181,0.0001826614,0.0005609096,0.00001252945,0.00006711924,0.0002357737],"genre_scores_gemma":[0.9903839,0.0007003802,0.006334312,0.001797613,0.0002580007,0.00006632415,0.00009600226,0.00006298238,0.0003004472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3244483,"threshold_uncertainty_score":0.8411878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02649108499386556,"score_gpt":0.3108909309257396,"score_spread":0.2843998459318741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}