{"id":"W3190517567","doi":"10.15252/emmm.202113929","title":"Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis","year":2021,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Medical Research Council; Instituto de Salud Carlos III; Università di Pisa; Generalitat de Catalunya; ZonMw; Nottingham Trent University; LAM Foundation; Lam Research; Tuberous Sclerosis Association","keywords":"Lymphangioleiomyomatosis; Histamine; Pharmacology; Biology; Aprepitant; Medicine; Cancer research; Bioinformatics; Internal medicine; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002496966,0.0003156066,0.0003672774,0.000351917,0.0001003406,0.0004567161,0.000187489,0.0004357693,0.0007534293],"category_scores_gemma":[0.0002043124,0.00009774644,0.0002321844,0.0002014358,0.0001962272,0.0003706558,0.0001816823,0.0005409886,0.0001846773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004340008,"about_ca_system_score_gemma":0.000205531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002999596,"about_ca_topic_score_gemma":0.0006008561,"domain_scores_codex":[0.9999124,0.00002511185,0.000007249013,0.0000182221,0.00001967082,0.00001729427],"domain_scores_gemma":[0.999881,0.00002075322,0.00005248244,0.000006152933,0.00001766762,0.00002196853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003377084,0.0003197949,0.03531849,0.00103431,0.0002237926,0.0009364552,0.00008225696,0.0007632196,0.7452199,0.001058413,0.002219962,0.2094464],"study_design_scores_gemma":[0.0007199525,0.00959297,0.3403827,0.000585007,0.001080085,0.007267401,0.0005448826,0.01009911,0.5413081,0.005529101,0.08276051,0.0001301271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7672061,0.2140397,0.008133056,0.004681773,0.0002592104,0.0001333983,0.0008381241,0.0003073753,0.004401267],"genre_scores_gemma":[0.9693431,0.02448725,0.003886488,0.0005969031,0.0001640892,0.00004805556,0.0003838232,0.00001213381,0.001078087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007534293,"threshold_uncertainty_score":0.003148854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02649108499386556,"score_gpt":0.3108909309257396,"score_spread":0.2843998459318741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}