{"id":"W3190575184","doi":"10.3390/cancers13164046","title":"Hypoxic Jumbo Spheroids On-A-Chip (HOnAChip): Insights into Treatment Efficacy","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Polytechnique Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé","keywords":"Spheroid; Tirapazamine; Cell culture; Hypoxia (environmental); Cancer research; Chemistry; Cytotoxicity; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002049852,0.0002197741,0.000317218,0.0002240794,0.0001173506,0.0002266681,0.000182279,0.000225592,0.001518276],"category_scores_gemma":[0.0001824565,0.0001358087,0.0001592177,0.0001224463,0.000143754,0.0001912419,0.000148008,0.0003647888,0.0003600772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002340452,"about_ca_system_score_gemma":0.0001854815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006476497,"about_ca_topic_score_gemma":0.001103353,"domain_scores_codex":[0.9998775,0.00001639231,0.000007209304,0.00002674722,0.00004904997,0.0000231323],"domain_scores_gemma":[0.9998988,0.00004460481,0.00001486852,0.00001058158,0.00001553803,0.00001556657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007065129,0.0000248453,0.0002251112,0.00008113848,0.000005851411,0.00002599249,0.00002490641,0.0003273582,0.9929036,0.0000832636,0.0003240513,0.005903265],"study_design_scores_gemma":[0.00001784106,0.0003954149,0.005546446,0.000006652933,0.0000195763,0.00009638356,0.00002570303,0.00376942,0.9848189,0.00007558655,0.005218015,0.000009989159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9350374,0.01283316,0.04250829,0.0005683218,0.0001873581,0.0001713592,0.002060938,0.0009200761,0.00571303],"genre_scores_gemma":[0.9738676,0.003047489,0.01829368,0.0001687824,0.00002842382,0.0002095796,0.0006496953,0.00008120958,0.003653501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001518276,"threshold_uncertainty_score":0.00507915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283726668992694,"score_gpt":0.2581801861275165,"score_spread":0.2453429194375896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}