{"id":"W3190575184","doi":"10.3390/cancers13164046","title":"Hypoxic Jumbo Spheroids On-A-Chip (HOnAChip): Insights into Treatment Efficacy","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Polytechnique Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé","keywords":"Spheroid; Tirapazamine; Cell culture; Hypoxia (environmental); Cancer research; Chemistry; Cytotoxicity; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003755461,0.0002570893,0.0002546594,0.00003285203,0.0001257441,0.0000326493,0.0001550334,0.0001549541,0.0001065486],"category_scores_gemma":[0.00005113452,0.0002357845,0.0002000695,0.0001498736,0.00009248062,0.000003964989,0.00005530192,0.00009202844,0.00005520153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000392773,"about_ca_system_score_gemma":0.001111062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000221312,"about_ca_topic_score_gemma":0.0007437522,"domain_scores_codex":[0.9987001,0.0000633081,0.000187654,0.0005793293,0.0001548967,0.0003147247],"domain_scores_gemma":[0.9990551,0.00001653396,0.00006158103,0.0005932921,0.00008035899,0.0001931115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002477011,0.0001618689,0.0001877185,0.00002852441,0.0003405568,0.00002434905,0.0007717834,0.001855183,0.8565362,0.0004667373,0.02477155,0.1146078],"study_design_scores_gemma":[0.001419073,0.0002799246,0.0009835152,0.00001532941,0.00004262745,0.000007151539,0.0001088188,0.00001629739,0.3150739,0.00008010231,0.6817457,0.0002275513],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642505,0.0249987,0.0001070473,0.0001461595,0.002933629,0.0001894313,0.00001661052,0.0000277013,0.007330228],"genre_scores_gemma":[0.9797605,0.008307524,0.0003528867,0.001247568,0.003359398,0.00007851188,0.0001939064,0.00005004773,0.006649625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6569741,"threshold_uncertainty_score":0.9615014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283726668992694,"score_gpt":0.2581801861275165,"score_spread":0.2453429194375896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}