{"id":"W3190598927","doi":"10.1128/msphere.00647-21","title":"Human Basigin (CD147) Does Not Directly Interact with SARS-CoV-2 Spike Glycoprotein","year":2021,"lang":"en","type":"article","venue":"mSphere","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; UK Research and Innovation; Government of Canada; Wellcome Trust; Medical Research Council; Wellcome","keywords":"Basigin; Coronavirus disease 2019 (COVID-19); Spike (software development); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Glycoprotein; 2019-20 coronavirus outbreak; Virology; Medicine; Intensive care medicine; Spike Protein; Computer science; Biology; Disease; Outbreak; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009073757,0.0001510517,0.0001564411,0.00006152844,0.0001061237,0.000229203,0.0002173108,0.0003470706,0.002465818],"category_scores_gemma":[0.0001565935,0.00006768222,0.0001931713,0.00005190225,0.0001280178,0.0001659733,0.0001550521,0.0002991599,0.0006816529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003746779,"about_ca_system_score_gemma":0.0001720806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205336,"about_ca_topic_score_gemma":0.001328684,"domain_scores_codex":[0.9998858,0.00002259124,0.000004564659,0.00002256097,0.00003223027,0.00003229898],"domain_scores_gemma":[0.9999518,0.00001307173,0.000009243107,0.000008978682,0.00000520014,0.00001157168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00019971,0.00002988866,0.0009693365,0.00004051161,0.00001657391,0.0001597435,0.000019156,0.0001112169,0.9948144,0.0003752422,0.0002762171,0.002988099],"study_design_scores_gemma":[0.0000354369,0.0003915003,0.01179848,0.00001187148,0.00002240411,0.002160874,0.00004869819,0.002528415,0.9648233,0.0001933025,0.01797803,0.000007654096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896469,0.002347343,0.002180143,0.0004015327,0.00004342902,0.00002306223,0.000338202,0.00003446314,0.004985039],"genre_scores_gemma":[0.9934155,0.0004320983,0.001185433,0.0001728761,0.0000117426,0.00001037761,0.00088609,0.000009270185,0.003876722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002465818,"threshold_uncertainty_score":0.008248985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01575226099832167,"score_gpt":0.2749338319094162,"score_spread":0.2591815709110945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}