{"id":"W3190598927","doi":"10.1128/msphere.00647-21","title":"Human Basigin (CD147) Does Not Directly Interact with SARS-CoV-2 Spike Glycoprotein","year":2021,"lang":"en","type":"article","venue":"mSphere","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; UK Research and Innovation; Government of Canada; Wellcome Trust; Medical Research Council; Wellcome","keywords":"Basigin; Coronavirus disease 2019 (COVID-19); Spike (software development); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Glycoprotein; 2019-20 coronavirus outbreak; Virology; Medicine; Intensive care medicine; Spike Protein; Computer science; Biology; Disease; Outbreak; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000832444,0.0002231726,0.0001786353,0.00001138661,0.00009545044,0.00006943401,0.0002353002,0.0001237263,0.000265094],"category_scores_gemma":[0.00008806039,0.0001729521,0.0001109919,0.00009621563,0.00007971291,0.000005066302,0.0001425344,0.0001321063,0.00004412099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002187148,"about_ca_system_score_gemma":0.0001297776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007180456,"about_ca_topic_score_gemma":0.0004575776,"domain_scores_codex":[0.9987453,0.00008178358,0.0001863298,0.0005293337,0.0001775339,0.0002797569],"domain_scores_gemma":[0.9991069,0.000008476833,0.00007689556,0.0006270776,0.000105805,0.00007485259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001152018,0.0001107181,0.001897275,0.00003896673,0.00007533684,0.0001848073,0.00003034449,0.00001413446,0.9928146,0.0000423911,0.003262587,0.001413621],"study_design_scores_gemma":[0.0005881664,0.0001633019,0.0004791153,0.00007692146,0.00002859878,0.0000254698,0.00005741318,0.000008013713,0.9612595,0.00005999261,0.0369683,0.0002852405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935678,0.000357942,0.000258844,0.0001895436,0.0001600065,0.0001537415,0.00005769799,0.00004746522,0.005206925],"genre_scores_gemma":[0.9940522,0.000006164247,0.001376152,0.0009897853,0.0002853571,0.0000448197,0.0001216923,0.00005261457,0.003071213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03370571,"threshold_uncertainty_score":0.7052784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01575226099832167,"score_gpt":0.2749338319094162,"score_spread":0.2591815709110945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}