{"id":"W3190699003","doi":"10.1089/nat.2020.0921","title":"Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides","year":2021,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Providence Health Care; Concordia University; Ontario Genomics","funders":"","keywords":"RNA splicing; In silico; Transcriptome; Alternative splicing; Computational biology; Biology; Oligonucleotide; False discovery rate; Exon skipping; RNA; Bioinformatics; Gene; Genetics; Gene expression; Exon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001395427,0.0004209481,0.0008435891,0.0002137958,0.0002032612,0.000645334,0.0002324877,0.0004745332,0.001387147],"category_scores_gemma":[0.001869869,0.0002071226,0.0005656858,0.000184508,0.0003453821,0.0001881823,0.0002301297,0.0005942692,0.0003354259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004297067,"about_ca_system_score_gemma":0.0002929477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005950026,"about_ca_topic_score_gemma":0.001125177,"domain_scores_codex":[0.9991478,0.000216368,0.00006509587,0.0002009047,0.0002766863,0.00009307219],"domain_scores_gemma":[0.9987336,0.0008201661,0.0001811716,0.00007754938,0.0001370967,0.00005036787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002526203,0.00006580938,0.002879089,0.0001306516,0.00003968762,0.00005844668,0.00002051263,0.004357709,0.9867014,0.0001464119,0.00009009551,0.005257591],"study_design_scores_gemma":[0.0000245219,0.000944156,0.02170835,0.00001648453,0.0001219227,0.0002081207,0.00005873052,0.03935234,0.9353936,0.0003395694,0.001807483,0.00002467348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98083,0.0008533418,0.01482715,0.0001272519,0.00006365373,0.00006665149,0.001105478,0.0003943643,0.001732194],"genre_scores_gemma":[0.9905902,0.0004067861,0.006487953,0.0002410673,0.00001010974,0.00006863397,0.001371855,0.00007250982,0.0007509675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001395427,"threshold_uncertainty_score":0.00737983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110649793272167,"score_gpt":0.2327224152035207,"score_spread":0.221657435876304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}