{"id":"W3190699003","doi":"10.1089/nat.2020.0921","title":"Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides","year":2021,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Providence Health Care; Concordia University; Ontario Genomics","funders":"","keywords":"RNA splicing; In silico; Transcriptome; Alternative splicing; Computational biology; Biology; Oligonucleotide; False discovery rate; Exon skipping; RNA; Bioinformatics; Gene; Genetics; Gene expression; Exon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001429347,0.0002143835,0.000270847,0.00003564681,0.00007848203,0.00002665167,0.000254481,0.0002017041,0.00007001055],"category_scores_gemma":[0.00005479706,0.00020997,0.0001924155,0.0001251722,0.00007153943,0.000005818033,0.00007116879,0.00009107802,0.00001116584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001004897,"about_ca_system_score_gemma":0.00006923216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001831044,"about_ca_topic_score_gemma":0.000002404905,"domain_scores_codex":[0.9987523,0.0001467829,0.0002751949,0.0003346381,0.000193167,0.0002978934],"domain_scores_gemma":[0.9991511,0.00004411954,0.0001139414,0.000503437,0.0001171994,0.00007022849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005903452,0.00009614017,0.0006087991,0.00008531697,0.0002019319,0.00001323177,0.0001821024,0.00000684969,0.9789321,0.0002665831,0.00006129037,0.01948665],"study_design_scores_gemma":[0.0004764254,0.0002215663,0.0006377365,0.00005367891,0.00006955896,0.00001403434,0.00009966169,0.00002396665,0.938575,0.0006392085,0.05897002,0.000219151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741355,0.01077527,0.01285427,0.0002464872,0.0004272547,0.0002156702,0.00001253577,0.00003027961,0.001302785],"genre_scores_gemma":[0.9889824,0.001196317,0.00787005,0.001419281,0.0001235394,0.00001474623,0.00002142866,0.00005917401,0.0003130019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05890873,"threshold_uncertainty_score":0.8562328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110649793272167,"score_gpt":0.2327224152035207,"score_spread":0.221657435876304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}