{"id":"W3190936437","doi":"10.1038/s41589-021-00854-y","title":"Structures and function of the amino acid polymerase cyanophycin synthetase","year":2021,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Government of Canada; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Eidgenössische Technische Hochschule Zürich; Canada Research Chairs","keywords":"Biochemistry; Transferase; Active site; Chemistry; Protein structure; Amino acid; Aspartic acid; Enzyme; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001935923,0.0004804335,0.0002764585,0.0002231137,0.0002757322,0.0008722579,0.0003010776,0.0004830445,0.001178707],"category_scores_gemma":[0.0003945594,0.0002097699,0.0001881276,0.0002390339,0.0005271002,0.0004895619,0.0002229159,0.0008945224,0.0005760069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001140408,"about_ca_system_score_gemma":0.0005675234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002251076,"about_ca_topic_score_gemma":0.001175908,"domain_scores_codex":[0.9999036,0.00002139974,0.000005680694,0.00002473887,0.00002323199,0.00002134691],"domain_scores_gemma":[0.9997527,0.00006572564,0.00005157536,0.00002861106,0.00003196087,0.00006940263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008219054,0.00005010441,0.001453234,0.0001045425,0.00001243154,0.0004908929,0.0001127929,0.003043077,0.9804732,0.005519018,0.0001732812,0.007745616],"study_design_scores_gemma":[0.00003505844,0.0002443226,0.006341762,0.00001540529,0.00001380393,0.0005631944,0.0001509172,0.004707127,0.9783205,0.002577151,0.007003529,0.00002725359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774876,0.007964223,0.007736383,0.0006269764,0.00005479151,0.00002122146,0.0004250037,0.000100708,0.005583255],"genre_scores_gemma":[0.9932345,0.001522301,0.002011142,0.00005126759,0.00001912634,0.000006808568,0.0007540018,0.00001950826,0.00238128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002251076,"threshold_uncertainty_score":0.008274198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006099707863827215,"score_gpt":0.2349437430517461,"score_spread":0.2288440351879189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}