{"id":"W3190966054","doi":"10.7554/elife.66524.sa2","title":"Author response: Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer","year":2021,"lang":"en","type":"peer-review","venue":"","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Alberta Children's Hospital; University of Calgary; BC Cancer Agency","funders":"","keywords":"Chromatin; Lineage (genetic); Cell biology; Transformation (genetics); Extracellular; Biology; Kinase; Lung cancer; Cancer research; Computational biology; Genetics; Medicine; Gene; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002873599,0.0004381036,0.0005258071,0.001285052,0.0008732962,0.002888591,0.0009384798,0.00194119,0.1248747],"category_scores_gemma":[0.01159865,0.0002343927,0.0003330253,0.0006698004,0.0009903277,0.001334715,0.00134738,0.001282451,0.04716279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000927241,"about_ca_system_score_gemma":0.002791873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006001857,"about_ca_topic_score_gemma":0.001480696,"domain_scores_codex":[0.9974332,0.000422211,0.0001747647,0.0003220073,0.001405559,0.0002422305],"domain_scores_gemma":[0.9879059,0.0020178,0.001020976,0.0007167826,0.006394645,0.00194396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001068859,0.0002424336,0.005595148,0.002148842,0.0001154781,0.001933231,0.0005446822,0.0006144142,0.05231962,0.01283385,0.528976,0.3936075],"study_design_scores_gemma":[0.00008186345,0.000164028,0.006674234,0.0001520564,0.00003781003,0.001391825,0.0005196466,0.0007310267,0.02225045,0.003479635,0.9644881,0.00002924638],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"commentary","genre_scores_codex":[0.1198301,0.06135431,0.01908677,0.2388797,0.1462727,0.001576222,0.007263654,0.003785799,0.4019507],"genre_scores_gemma":[0.1605655,0.01872494,0.005172343,0.00865307,0.01686831,0.0001372484,0.002550698,0.0004344446,0.7868934],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.1248747,"threshold_uncertainty_score":0.4177473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02815419192497084,"score_gpt":0.3418466692905764,"score_spread":0.3136924773656056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}