{"id":"W3191021353","doi":"10.1101/gad.348634.121","title":"Three-layered control of mRNA poly(A) tail synthesis in <i>Saccharomyces cerevisiae</i>","year":2021,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Danmarks Frie Forskningsfond; Novo Nordisk Fonden; Medical Research Council Canada; Federation of European Biochemical Societies; Novo Nordisk; Lundbeckfonden; Fundacja na rzecz Nauki Polskiej; European Commission; European Molecular Biology Organization; Gates Cambridge Trust; UK Research and Innovation","keywords":"Polyadenylation; Biology; Saccharomyces cerevisiae; Messenger RNA; Poly(A)-binding protein; Cleavage (geology); RNA-binding protein; Translation (biology); Cell biology; Protein biosynthesis; Molecular biology; Biogenesis; RNA; Cleavage and polyadenylation specificity factor; Primary transcript; Nuclear export signal; Yeast; Biochemistry; Gene; Alternative splicing","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002712733,0.0001425101,0.0002399255,0.00005453039,0.00005174396,0.00001939234,0.0001986693,0.00009383946,0.00006905213],"category_scores_gemma":[0.0001085865,0.00013504,0.00006832517,0.0001401237,0.00003364688,0.000003482631,0.000131294,0.00006106442,0.00001348611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002590408,"about_ca_system_score_gemma":0.0004656817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004831869,"about_ca_topic_score_gemma":0.0004466876,"domain_scores_codex":[0.9987299,0.00005596719,0.0003274687,0.0003263151,0.0002210334,0.0003392826],"domain_scores_gemma":[0.9994135,0.00002922403,0.00007118462,0.0002772228,0.0001168004,0.00009203212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000641645,0.00005923944,0.03470344,0.00004453043,0.00008818817,0.00002329268,0.00002960314,0.00001819602,0.8727056,0.00002245358,0.0001911505,0.09205014],"study_design_scores_gemma":[0.0005439759,0.00003077892,0.02265363,0.00005326754,0.000006791788,0.00001165499,0.00009163502,0.00004544855,0.9581534,0.00001804078,0.01822514,0.0001662934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822302,0.01335989,0.003500635,0.0003075058,0.00005813865,0.0001444915,0.00001088535,0.000006013999,0.0003821932],"genre_scores_gemma":[0.9937627,0.0009928816,0.004595974,0.0001418834,0.0000553788,0.00006042778,0.00002576096,0.00001644883,0.0003485318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09188385,"threshold_uncertainty_score":0.5506771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282953738664253,"score_gpt":0.2439172796263154,"score_spread":0.2310877422396729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}