{"id":"W3191021353","doi":"10.1101/gad.348634.121","title":"Three-layered control of mRNA poly(A) tail synthesis in <i>Saccharomyces cerevisiae</i>","year":2021,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Danmarks Frie Forskningsfond; Novo Nordisk Fonden; Medical Research Council Canada; Federation of European Biochemical Societies; Novo Nordisk; Lundbeckfonden; Fundacja na rzecz Nauki Polskiej; European Commission; European Molecular Biology Organization; Gates Cambridge Trust; UK Research and Innovation","keywords":"Polyadenylation; Biology; Saccharomyces cerevisiae; Messenger RNA; Poly(A)-binding protein; Cleavage (geology); RNA-binding protein; Translation (biology); Cell biology; Protein biosynthesis; Molecular biology; Biogenesis; RNA; Cleavage and polyadenylation specificity factor; Primary transcript; Nuclear export signal; Yeast; Biochemistry; Gene; Alternative splicing","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002216718,0.0004185345,0.0002448882,0.0001811588,0.0002287947,0.0009459979,0.00030203,0.0001788101,0.0005011356],"category_scores_gemma":[0.0002292045,0.0002130815,0.0002171449,0.0001423538,0.0003552813,0.0001442006,0.0003099801,0.0005824788,0.0003133325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001133572,"about_ca_system_score_gemma":0.0004471044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003062537,"about_ca_topic_score_gemma":0.003434079,"domain_scores_codex":[0.9997823,0.0000334458,0.00003102567,0.00006171438,0.00006425357,0.0000273344],"domain_scores_gemma":[0.9997283,0.00004973621,0.00007424114,0.00004048298,0.00003797766,0.00006920557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008741028,0.00001692712,0.0002478065,0.00002584523,0.000003500769,0.00002592843,0.00001975877,0.0002242223,0.9972141,0.0002910988,0.0000413231,0.001802161],"study_design_scores_gemma":[0.000006448419,0.00003728339,0.000773042,0.000002433593,0.000005902055,0.00003523655,0.00001137588,0.00217865,0.9956026,0.00007326285,0.001266772,0.000006915221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786196,0.00113704,0.01638077,0.0001324553,0.00007752229,0.00005925322,0.000634781,0.0007976408,0.002160857],"genre_scores_gemma":[0.9828382,0.0004771625,0.0136742,0.00005547614,0.000008674221,0.00004133846,0.000445076,0.0001218461,0.002338056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003062537,"threshold_uncertainty_score":0.008224726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282953738664253,"score_gpt":0.2439172796263154,"score_spread":0.2310877422396729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}