{"id":"W3191050526","doi":"10.1038/s41434-021-00281-7","title":"XIAP gene therapy effects on retinal ganglion cell structure and function in a mouse model of glaucoma","year":2021,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Glaucoma Research Society of Canada","keywords":"XIAP; Retinal ganglion cell; Glaucoma; Optic nerve; Biology; Inhibitor of apoptosis; Neuroprotection; Programmed cell death; Neuroscience; Apoptosis; Caspase; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003932146,0.0006898676,0.0005433137,0.00170441,0.0004340926,0.0004705242,0.0004663197,0.001105848,0.00277799],"category_scores_gemma":[0.0002272151,0.0004197753,0.0004767097,0.0004564714,0.0009860994,0.0006329155,0.0002621311,0.001606978,0.0003357529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000531045,"about_ca_system_score_gemma":0.0004453455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001610402,"about_ca_topic_score_gemma":0.001698061,"domain_scores_codex":[0.9996921,0.00004871505,0.00003805677,0.00006591837,0.00008314717,0.00007210907],"domain_scores_gemma":[0.9995708,0.00008733939,0.0001348709,0.00005034004,0.0000242165,0.0001323987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005802825,0.0001918878,0.0001421106,0.00003318024,0.00001001735,0.0001871104,0.00003880955,0.0001164932,0.997163,0.0003584366,0.00007615393,0.001102436],"study_design_scores_gemma":[0.000162895,0.00147289,0.002155544,0.00001430185,0.00006694844,0.0003907555,0.00007878313,0.001013475,0.993194,0.0001812412,0.001256328,0.00001294691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936799,0.001601861,0.001737059,0.0003409499,0.00009996144,0.00005248854,0.0005181048,0.0002239038,0.001745816],"genre_scores_gemma":[0.9876701,0.001224974,0.002224187,0.0001206986,0.00002144882,0.0000931488,0.0003372151,0.00007175146,0.008236491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00277799,"threshold_uncertainty_score":0.009293318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00958121045722638,"score_gpt":0.2265853527542613,"score_spread":0.2170041422970349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}