{"id":"W3191093894","doi":"10.1038/s41467-021-24983-z","title":"Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Saskatchewan; Institute of Infection and Immunity; University of Ottawa; Hospital for Sick Children; SickKids Foundation; University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; Canadian Institutes of Health Research; Hospital for Sick Children; Ontario Innovation Trust","keywords":"Effector; GTPase; Salmonella; Virulence; Dynamin; Cell biology; Vacuole; Biology; Pathogen; Cell membrane; Cell; Microbiology; Biochemistry; Bacteria; Gene; Genetics; Endocytosis; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000982343,0.0001975113,0.0001677313,0.0001195814,0.0001139787,0.0002866307,0.0001808528,0.0002366644,0.001098913],"category_scores_gemma":[0.0001188951,0.00009732019,0.0001887696,0.00004655025,0.000209178,0.0001563011,0.0002675966,0.0004545442,0.0003156279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000284006,"about_ca_system_score_gemma":0.0002475426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005004298,"about_ca_topic_score_gemma":0.0006769914,"domain_scores_codex":[0.9998934,0.00001847082,0.000008294976,0.0000173116,0.00003056076,0.00003188179],"domain_scores_gemma":[0.9999049,0.00002110631,0.00002070009,0.00001223877,0.00001241314,0.00002859943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001501859,0.00003048704,0.0001559601,0.0000218762,0.00000258434,0.00002931605,0.000006277171,0.0000729272,0.9987199,0.0001076858,0.00004820649,0.0006545215],"study_design_scores_gemma":[0.000008129633,0.0001447125,0.001672282,0.000002431874,0.000003152437,0.00007146342,0.00001552602,0.0009865724,0.9960395,0.00002420145,0.001030274,0.000001672571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958841,0.0004233239,0.001601527,0.0001326919,0.00001951776,0.00001116805,0.0001040354,0.00007869485,0.001745053],"genre_scores_gemma":[0.9971268,0.0002032538,0.0008409153,0.0000440859,0.000003481874,0.000009877504,0.0001420927,0.00001062705,0.001618946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001098913,"threshold_uncertainty_score":0.003676176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009285835628225892,"score_gpt":0.255735769160454,"score_spread":0.2464499335322282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}